ArticleBMC medicine2026
Sodium-glucose cotransporter 2 inhibitors and the risk of kidney cancer among patients with type 2 diabetes: a population-based cohort study.
Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThere is an important need to develop clinical strategies to reduce the risk of incident kidney cancer, especially in patients with type 2 diabetes (T2D) often accompanied by chronic kidney disease. Here, we investigated whether sodium-glucose cotransporter 2 (SGLT2) inhibitor use is associated with reduced kidney cancer risk compared to dipeptidyl peptidase-4 (DPP-4) inhibitor use in patients with T2D, using a nationwide cohort of the Korean national health insurance claims and health examination database.
methodsAfter 1:1 propensity score matching, 57,103 SGLT2 inhibitor new users and 57,103 DPP-4 inhibitor new users were selected from 581,702 kidney cancer-free participants, aged 20 to 79 years, who started oral glucose-lowering drugs for T2D from 2014 to 2018.
resultsDuring 408,481 person-years of follow-up, 102 (25.0 per 100,000 person-years) new kidney cancer events occurred. SGLT2 inhibitor use was associated with a 40% reduced risk of kidney cancer compared with DPP-4 inhibitor use (18.9 vs. 30.8 per 100,000 person-years; hazard ratio [HR] 0.60, 95% CI 0.40 to 0.89). The reduced kidney cancer risk associated with SGLT2 inhibitor use versus DPP-4 inhibitor use was consistent even after additional adjustment for all variables composing the propensity scores (HR 0.60, 95% CI 0.40 to 0.90) and regardless of age, sex, body mass index, current smoking, hypertension, medication use, or diabetic complications including nephropathy (all p > 0.05 for interaction). When comparing SGLT2 inhibitor users with 1:1 propensity score-matched non-users, SGLT2 inhibitor use was associated with a 34% reduced risk of kidney cancer compared to non-use (HR 0.66, 95% CI 0.49 to 0.89).
conclusionsOur findings suggest a potential association between SGLT2 inhibitor use and a lower risk of kidney cancer, which needs to be further validated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.