ArticleRespiratory research2026
Identification of oxygenation impairment-associated gene networks in ARDS through integrated mRNA and miRNA analysis.
Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Investigating the Role of microRNA in Host-Influenza A and Other Respiratory RNA Virus Interactions.Pathogens (Basel, Switzerland) · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundAcute respiratory distress syndrome (ARDS) is associated with high mortality and complex pathophysiology, yet molecularly targeted therapies remain undeveloped. In particular, the microRNA (miRNA)-mRNA regulatory network underlying ARDS is poorly understood. This study aimed to elucidate the miRNA-mRNA interactions associated with the pathophysiology of ARDS.
methodsmRNA-Seq and miRNA-Seq were performed in 34 patients with ARDS and healthy controls. Gene and miRNA co-expression modules were constructed using Weighted Gene Co-expression Network Analysis. miRNA-mRNA regulatory relationships were inferred through an integrated analysis of predicted and experimentally validated miRNA targets. Molecular signatures were quantified via single-sample gene set enrichment analysis, and module structure preservation was evaluated in an external pneumonia cohort.
resultsA key mRNA co-expression module was identified that exhibited the strongest negative correlation with the P/F ratio, along with a negatively correlated miRNA co-expression module. The miRNA module, centered on miR-361-5p and miR-186-5p, formed a regulatory network broadly controlling gene clusters involved in ubiquitin ligase activity and cellular stress response pathways. This network demonstrated a strong association with the P/F ratio and showed high structural preservation in the external pneumonia cohort.
conclusionA miRNA-mRNA regulatory network linked to impaired oxygenation in patients with ARDS has been identified. The network highlights miRNAs as potential key regulators of disease progression and suggests their utility as biomarkers of disease severity and prospective therapeutic targets.
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