Evidence map›Paper›PMID 42121097›Full record

ArticleBMC pediatrics2026

A comparative study on the risk of acute kidney injury in children induced by iso-osmolarity and low-osmolarity contrast media.

Fang Hu, Chen Wang, Ruohua Yan, Xiaohang Liu, Jihang Sun, Yun Peng, Xiaoxia Peng

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fang HuCenter for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Chen WangCenter for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Ruohua YanCenter for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Xiaohang LiuCenter for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Jihang SunImaging Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Yun Peng *Imaging Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China. ppengyun@hotmail.com.
Xiaoxia Peng *Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China. pengxiaoxia@bch.com.cn.

Funding

National Natural Science Foundation of China Grant No. 72174128
6 · The paper itself

Abstract

backgroundTo compare the risk of contrast-associated acute kidney injury (CA-AKI) caused by iso-osmolarity contrast media (IOCM) and low-osmolarity contrast media (LOCM) in pediatric patients.

methodsA retrospective cohort exposed to contrast-enhanced CT was constructed based on the inpatients from Beijing Children's Hospital (2015-2020). The patients were divided into IOCM and LOCM exposure. AKI was defined by the pediatric version of Kidney Disease: Improving Global Outcomes (KDIGO, pKDIGO) criteria. After adjusting baseline differences with inverse probability of treatment weighting (IPTW), log-binomial regression was conducted to estimate the risk ratios (RR) and 95% confidence interval (CI) of AKI between the IOCM and LOCM groups. Subgroup analyses were performed by age (< 2 vs. ≥2 years), ICU status, CT scan site, and sex.

resultsOf 6081 pediatric patients exposed to CT enhanced scans, 1004 children were eligible for inclusion and exclusion criteria, in which there were 545 (54.3%) and 459 (45.7%) patients in the IOCM and LOCM groups, respectively. The unadjusted incidence of AKI in the IOCM (12.1%) was higher than that in LOCM (6.1%). However, the adjusted relative risk (aRR) indicated a significantly lower risk of CA-AKI with IOCM compared to LOCM (aRR: 0.54, 95% CI: 0.40-0.73).

conclusionsIn the pediatric cohort, IOCM was associated with a significantly lower risk of CA-AKI compared to LOCM. This association was consistently observed across key subgroups, such as age, sex, and ICU status.

Indexed as

Acute Kidney InjuryContrast MediaAdolescentChildChild, PreschoolFemaleHumansIncidenceInfantMaleOsmolar ConcentrationRetrospective StudiesRisk FactorsTomography, X-Ray ComputedContrast MediaAcute kidney injuryChildrenIso-osmolarity contrast mediaLow-osmolarity contrast media

Identifiers

PMID42121097
PMCPMC13339257

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.