ArticleBMC cancer2026
Expressional deregulations of RET/PTC genes and different nutritional factors playing crucial role in the development of thyroid cancer in Pakistani female subjects.
Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe most common endocrine malignancy occurring in the human population is thyroid cancer (TC), and its subtype papillary thyroid carcinoma (PTC) constitutes about 80%-90% of all thyroid cancers. It is implicated that certain dietary habits are playing important role in carcinogenesis. It is also suggested through genetic studies that the key step in the pathogenesis of thyroid cancer is the Rearrangements during transfection (RET).
aimsThis study was planned to analyze the role of both dietary habits and RET/PTC aberrations in the Pakistani population. METHODOLOGY: Data about clinical, demographic hallmarks, and nutritional factors were collected through a questionnaire. Thyroid cancer tissue samples were collected along with adjacent normal samples. RNA was extracted through the TRIzol method, and cDNA was synthesized. The samples were checked for their expression deregulations of RET/PTC1 and RET/PTC3 through quantitative Real-Time PCR compared to normal controls. Data were analyzed statistically using SPSS.
resultsStage 1 &2 thyroid cancer patients were frequent. Increased risk of thyroid cancer was observed to be associated with meat consumption and dairy products. Increased expression of RET/PTC1 and RET/PTC3 at significant levels (p -value p < 0.05) was observed in thyroid cancer tissue as compared to normal and MNG specimens. Mean fold-change values exceeded 4-fold for RET/PTC1 and 6-fold for RET/PTC3, and both genes showed statistically significant overexpression (RET/PTC1: p < 0.0001; RET/PTC3: p = 0.0001).
conclusionThe present study postulates that some of the major nutritional factors can be significantly associated with thyroid carcinogenesis. While the RET/PTC rearrangements are the prime concern in thyroid cancer in the Pakistani population. The higher expression of RET/PTC1 and RET/PTC3 identified in thyroid cancer patients presents the potential target to be down regulated customized molecular therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.