Evidence map›Paper›PMID 42121038›Full record

ArticleBMC plant biology2026

Deciphering lipid biosynthesis and regulation in Isatis species through combined metabolomic and transcriptomic analysis.

Rong Chen, Qin Liu, Qiaoyun Cai, Yan Qing, Lili Wang, Fanglin Liu, Huijun Cheng, Xiaoshan Geng, Huaxi Huang, Xiaolu Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Rong Chen *Key Laboratory for Resource Plants Protection and Utilization of Yili Valley in Xinjiang, College of Biological Sciences and Technology, Yili Normal University, Yining, Xinjiang, 835000, China.
Qin Liu *College of Agricultural Engineering, Guangxi Vocational University of Agriculture, Nanning, 530000, China.
Qiaoyun Cai *Key Laboratory for Resource Plants Protection and Utilization of Yili Valley in Xinjiang, College of Biological Sciences and Technology, Yili Normal University, Yining, Xinjiang, 835000, China.
Yan QingKey Laboratory for Resource Plants Protection and Utilization of Yili Valley in Xinjiang, College of Biological Sciences and Technology, Yili Normal University, Yining, Xinjiang, 835000, China.
Lili WangKey Laboratory for Resource Plants Protection and Utilization of Yili Valley in Xinjiang, College of Biological Sciences and Technology, Yili Normal University, Yining, Xinjiang, 835000, China.
Fanglin LiuKey Laboratory for Resource Plants Protection and Utilization of Yili Valley in Xinjiang, College of Biological Sciences and Technology, Yili Normal University, Yining, Xinjiang, 835000, China.
Huijun ChengKey Laboratory for Resource Plants Protection and Utilization of Yili Valley in Xinjiang, College of Biological Sciences and Technology, Yili Normal University, Yining, Xinjiang, 835000, China.
Xiaoshan GengCollege of Agricultural Engineering, Guangxi Vocational University of Agriculture, Nanning, 530000, China.
Huaxi HuangKey Laboratory for Resource Plants Protection and Utilization of Yili Valley in Xinjiang, College of Biological Sciences and Technology, Yili Normal University, Yining, Xinjiang, 835000, China. 18176608120@163.com.
Xiaolu ChenKey Laboratory for Resource Plants Protection and Utilization of Yili Valley in Xinjiang, College of Biological Sciences and Technology, Yili Normal University, Yining, Xinjiang, 835000, China. cxl8109@163.com.

Funding

Project Supported by the Rural Science and Technology Entrepreneurship Action of Science and Technology Commissioners in Xinjiang Uygur Autonomous Region 2025KZ014Special Science and Technology Project of Ili Autonomous Prefecture YJC2025B03The Third Batch of Tianchi Innovation Leading Talent Fund of Xinjiang Autonomous Region 2025CXLJ004Xinjiang Autonomous Region Science and Technology Aid Program 2024E02010
6 · The paper itself

Abstract

Lipids play multifaceted roles beyond structure and storage, yet their diversity within medicinally important genera like Isatis is poorly characterized. This study conducted the integrated lipidomic and transcriptomic analysis of three Isatis species, namely, I. oblongata, I. tinctoria, and I. indigotica. Lipidomics identified 324 metabolites, with isoprene lipids being most abundant. Analysis revealed a conserved core lipidome (301 metabolites) alongside species-unique compounds. Statistical and machine-learning screening of 215 differential lipids identified six key metabolites with strong species-specific patterns, serving as potential chemical markers. Transcriptomics uncovered thousands of differentially expressed genes, including a conserved core set. Integrated analysis established a plausible transcriptional basis for the gradient accumulation of LysoPE 18:1, linked to differential expression of PLA2 and LPEAT genes. This multi-omics resource elucidates the regulatory basis of lipid metabolic divergence in Isatis, establishing a foundational framework for chemotaxonomy and future metabolic engineering in this genus.

Indexed as

LipidsTranscriptomeGene Expression ProfilingGene Expression Regulation, PlantLipid MetabolismLipidomicsMetabolomicsMultiomicsLipidsChemotaxonomyIsatisLipidomicsMulti-omics integrationSpecies differentiation

Identifiers

PMID42121038
PMCPMC13340001

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.