ArticleBMC anesthesiology2026
Effect of maternal body mass index on the dosage of metaraminol for preventing hypotension after spinal anesthesia.
Article in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo compare the median effective dose (ED
methodsEighty full-term singleton parturients scheduled for elective cesarean delivery at Suzhou Municipal Hospital Affiliated with Nanjing Medical University from July to September 2024 were selected and divided into a standard group (Group S, BMI < 30 kg/m²) and an obese group (Group O, BMI ≥ 30 kg/m²) based on BMI. All parturients underwent spinal anesthesia. Immediately after successful dural puncture, a continuous infusion of metaraminol was initiated. The initial dose for both groups was set at 2 mg, with a concentration of 0.02 mg/mL and a fixed infusion rate of 100 mL/h. The sequential method was used to adjust the dose for subsequent parturients, with a dose gradient of 0.05 mg: if the previous parturient developed hypotension, the dose for the next parturient was increased by 0.05 mg; if hypotension did not occur, the dose for the next parturient was decreased by 0.05 mg. Hypotension was defined as a systolic blood pressure (SBP) decrease of ≥ 20% from baseline or SBP < 90 mmHg. Probit regression analysis was used to calculate the ED
resultsThe ED
conclusionThe dose of metaraminol required to prevent hypotension after spinal anesthesia for cesarean delivery is influenced by maternal BMI. Obese parturients (BMI ≥ 30 kg/m²) require a higher dose of metaraminol. Therefore, it is reasonable to individualize the prophylactic dose of metaraminol based on maternal weight (BMI) in clinical practice.
trial registrationThe trial protocol was registered in the Chinese Clinical Trial Registry on June 29, 2024, with the registration number ChiCTR2400086366.
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