Evidence map›Paper›PMID 42121028›Full record

ReviewBMC genomics2026

Understanding super enhancers in genome architecture and their roles in livestock breeding.

Jie Cheng, Xiukai Cao, Kai Yang, Yuee Gao, Zexuan Hong, Xudong Tang, Ping Qian, Bizhi Huang

Abstract readReview
In one paragraph

Review in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jie ChengJiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
Xiukai CaoJoint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, 225009, China.
Kai YangYunnan Academy of Grassland and Animal Science, Kunming, 650000, China.
Yuee GaoYunnan Academy of Grassland and Animal Science, Kunming, 650000, China.
Zexuan HongYunnan Academy of Grassland and Animal Science, Kunming, 650000, China.
Xudong TangJiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
Ping QianJiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China. qianping@just.edu.cn.
Bizhi HuangYunnan Academy of Grassland and Animal Science, Kunming, 650000, China. ynbphbz@163.com.

Funding

Natural Science Foundation of Jiangsu Province BK20251003Youth Science Fund Project 32502871Yunnan Province Joint Laboratory of Seed Industry Yunling Cattle Breeding Project 202205AR070001-18
6 · The paper itself

Abstract

Super enhancers (SEs) are crucial regulatory elements in the genome that determine cell identity and fate commitment through mechanisms such as recruiting transcription factors (TFs), interacting with super enhancers RNAs (seRNAs), and phase separation. This ensures accurate gene expression in response to both environmental and intrinsic signals. Advances in 3D genome architecture have further illuminated how SEs are organized and regulated within the nucleus, thereby enhancing our understanding of their function. Recent innovations in genomic technologies, including chromatin accessibility, CRISPR-Cas9, 3 C-based methods and imaging methods, have revolutionized the study of SEs. These technologies have facilitated precise mapping and functional characterization, providing deeper insights into how SEs influence gene regulation. In particular, these advancements offer promising potential for exploring SE dynamics in livestock improvement, opening avenues for the enhancement of agricultural and breeding practices.

Indexed as

BreedingGenomeGenomicsLivestockSuper EnhancersAnimalsGene Expression Regulation3D genomeGene regulationLivestock biotechnologyMolecular breedingSuper Enhancers

Identifiers

PMID42121028
PMCPMC13335216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.