Evidence map›Paper›PMID 42120911›Full record

ReviewNature cancer2026

Harnessing myeloid cell plasticity for cancer therapy.

Emilio Sanseviero, Simon T Barry, Dmitry I Gabrilovich

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emilio Sanseviero *ICC, Oncology R&D, AstraZeneca, Gaithersburg, MD, USA.
Simon T Barry *OTD, Oncology R&D, AstraZeneca, Cambridge, UK.ORCID http://orcid.org/0000-0002-8511-0588
Dmitry I GabrilovichICC, Oncology R&D, AstraZeneca, Gaithersburg, MD, USA. Dmitry.gabrilovich@astrazeneca.com.ORCID http://orcid.org/0000-0001-9913-6407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myeloid cells have a multifaceted role in cancer, promoting tumor progression through angiogenesis, metastasis and immune suppression, as well as stimulating antitumor immunity. Traditionally, this dual functionality was attributed to cell heterogeneity, but it appears that myeloid cell plasticity is a more fundamental cancer trait. In this Review, we discuss two types of plasticity that enable myeloid cells to adjust to the tumor environment: differentiation plasticity, characterized by increased myelopoiesis and shifting differentiation patterns, and functional plasticity, marked by the adoption of pathological activation states. We assess the challenges to myeloid cell targeting in cancer and propose adaptable therapeutic strategies to overcome them.

Indexed as

Cell PlasticityMyeloid CellsNeoplasmsAnimalsCell DifferentiationHumansMyelopoiesisNeovascularization, PathologicTumor Microenvironment

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.