ArticleSpine deformity2026
Radiation-free assessment of the 3D morphology of the adolescent scoliotic spine: a feasibility study using MRI derived quantitative synthetic CT.
Article in Spine deformity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Statistical shape modelling of the human lumbar spine: a scoping review characterising the research landscape and potential clinical applications.Frontiers in bioengineering and biotechnology · 2026Pooled it
- The safety and accuracy of radiation-free spinal navigation using a short, scoliosis-specific BoneMRI-protocol, compared to CT.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Quantification of Thoracic Volume and Spinal Length of Pediatric Scoliosis Patients on Chest MRI Using a 3D U-Net Segmentation.Healthcare (Basel, Switzerland) · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTreatment management of pediatric spinal deformity patients heavily relies on radiological imaging; always with X-rays and sometimes CT scans to better delineate 3D morphology, and increasingly for navigation purposes. It is important to minimize radiation exposure in this vulnerable pediatric population, since it increases the risk for cancer development. This pilot study investigates the feasibility and reliability of 3D-spinal parameters identified on MRI-based quantitative synthetic CTs (sCTs) to assess scoliosis in adolescents.
methodsTen pre-operative MRI's from adolescent idiopathic scoliosis patients (mean age: 13.5 years) with curves on standing x-ray > 40° were included. A 4-min 3D spoiled gradient echo MRI sequence capturing the main thoracic curve was added to the clinical sequences and quantitative sCTs were generated. Three independent observers measured Cobb angle, T4-T12 thoracic kyphosis (TK) and apical vertebral rotation (AVR). Interrater reliability and 95% confidence intervals (CI) were calculated.
resultsThe sCTs clearly visualized the vertebral bodies and posterior elements, allowing for easy landmark identification to assess spinal morphology parameters of individual discs and vertebral bodies. Minor artifacts were observed in intervertebral discs and near the respiratory tract, not affecting the landmark positioning. The interrater reliability ICCs were Cobb angle: 0.99 (95% CI 0.98-1.00), TK: 0.98 (0.95-1.00) and AVR: 0.95 (0.86-0.99).
conclusionThis pilot study confirms that sCT derived from MRI allows for radiation-free and reliable measurement of 3D deformity parameters in AIS patients. While further research is needed, these findings demonstrate the potential for high-quality MRI-based bone imaging and its possible application in AIS treatment planning.
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