ArticleMikrochimica acta2026
ZIF-8 based on plasmonic metal organic framework hybrid gold nanoparticles for ultra-sensitive and multi-channel SERS detection of urinary metabolites.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
High-sensitivity and multiplex detection of urinary metabolites remain challenging in clinical diagnosis. In this work, a novel nanocomposite consisting of gold nanoparticles (AuNPs) deposited on the metal-organic framework ZIF-8 (denoted as ZIF-8@AuNPs) was designed and employed as a surface-enhanced Raman scattering (SERS) substrate for the simultaneous quantitative detection of adenosine triphosphate (ATP), uric acid (UA), adenine (Ade), and creatinine (Cr). The SERS substrate synergistically integrates the electromagnetic enhancement of AuNPs with the molecular enrichment capability of ZIF-8. The ZIF-8@AuNPs composite was comprehensively characterized using scanning electron microscopy, transmission electron microscopy, N
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