Evidence map›Paper›PMID 42120733›Full record

ArticleNature aging2026

Brain endothelial cell-derived extracellular vesicles (c-BEEVs) as a promising biomarker for brain vascular pathology and cognitive decline.

Tongyao You, Yingzhe Wang, Jun Xu, Yanxin Zhao, Sisi Peng, Qi Han, Xun Wang, Minjie Zhang, Weiwei Shen, Min Guo and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tongyao You *Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Yingzhe Wang *Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Jun Xu *Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0001-7432-6781
Yanxin Zhao *Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Sisi Peng *Department of Neuropsychology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Qi HanDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Xun WangDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Minjie ZhangDepartment of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Weiwei ShenDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Min GuoDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Junjian ZhangDepartment of Neuropsychology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Hailun YuCarrier Biomed (Suzhou) Company, Suzhou, China.
Jintai YuDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China. jintai_yu@fudan.edu.cn.ORCID http://orcid.org/0000-0002-2532-383X
Qiang DongDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China. dong_qiang@fudan.edu.cn.ORCID http://orcid.org/0000-0002-3874-0130
Mei CuiDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China. cuimei@fudan.edu.cn.ORCID http://orcid.org/0000-0002-6449-8106

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021YFC2500100Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) STI2030-Major Projects 2030 2021ZD0201806National Natural Science Foundation of China (National Science Foundation of China) 82271221Shanghai Municipal Health Bureau (Shanghai Municipal Public Health Bureau) 20234Z0013
6 · The paper itself

Abstract

Accurate measurement of brain vascular pathology is essential for understanding its role in cognitive aging. Here we classified participants using the amyloid-tau-neurodegeneration framework in a multicenter cohort and identified cerebrospinal fluid brain endothelial-derived small extracellular vesicles (c-BEEVs) as a sensitive biomarker, which correlated with vascular risk factors and the severity of small-vessel disease. c-BEEVs showed high diagnostic performance for vascular cognitive impairment and, when combined with p-tau181, effectively distinguished vascular cognitive impairment from Alzheimer's disease. In individuals with mixed Alzheimer's disease and vascular pathology, c-BEEVs were the earliest indicators of abnormalities. It predicted cognitive decline in participants without p-tau181 pathology. To investigate the mechanistic role of c-BEEVs, we established a hypertension mouse model with elevated c-BEEVs and cognitive deficits. Brain endothelial-specific knockdown of extracellular vesicle secretion alleviated cognitive and synaptic impairment. These findings position c-BEEVs as a promising biomarker for brain vascular pathology and highlight their role in neurovascular dysfunction.

Indexed as

BrainCognitive DysfunctionEndothelial CellsExtracellular VesiclesAgedAlzheimer DiseaseAnimalsBiomarkersDisease Models, AnimalFemaleHumansMaleMicetau ProteinsBiomarkerstau Proteins

Identifiers

PMID42120733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.