ArticleCellular and molecular life sciences : CMLS2026
MicroRNA-29 acutely regulates memory stability, expression of synaptic genes, and DNA methylation in the mouse adult hippocampus.
Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Reduced MOV10 reveals novel functional cortical connections in an increased fear response.bioRxiv : the preprint server for biology · 2026Article
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8 authors.
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Abstract
MicroRNAs are key regulators of brain gene expression, with miR-29 family notably upregulated from development to adulthood and in aging, and showing links to cognitive decline. However, the extent to which miR-29 levels influence learning and memory processes, and its molecular mediators, remains to be determined. Here, we down- and up-regulated miR-29 levels in the dorsal hippocampus of adult mice to reveal miR-29 role in memory. Inhibition of miR-29 enhanced trace fear memory stability, increased Dnmt3a levels, and promoted DNA methylation in a DNMT3a-dependent manner. In contrast, increasing miR-29 impaired memory performances and decreased Dnmt3a levels, suggesting a destabilization of memory processes. Proteomic and transcriptomic analysis demonstrated that miR-29 antagonism upregulated RNA-binding and synaptic proteins and downregulated inflammation and myelin associated proteins. These results underscore miR-29's pivotal role in memory persistence, plasticity, and cognitive aging, suggesting that miR-29 modulation could offer potential strategies for cognitive enhancement and age-related memory decline.
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