Evidence map›Paper›PMID 42120649›Full record

ArticleScientific reports2026

Trends in age-standardized incidence rates of cancers of HPV-related cancer sites in Osaka, Japan: 1977-2019.

Asami Yagi, Sayaka Ikeda, Atsuko Sakakibara, Yuri Ito, Tomio Nakayama, Yumi Ohta, Eiji Kobayashi, Kayo Nakata, Toshitaka Morishima, Isao Miyashiro and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Asami YagiDepartment of Advanced Prevention and Health Sciences, Wakayama Medical University, 811-1, Kimiidera, Wakayama, Wakayama, 641-8509, Japan. asamiy@wakayama-med.ac.jp.
Sayaka IkedaDepartment of Advanced Prevention and Health Sciences, Wakayama Medical University, 811-1, Kimiidera, Wakayama, Wakayama, 641-8509, Japan.
Atsuko SakakibaraDepartment of Preventive Medicine, Tazuke Kofukai Medical Research Institute, Kitano Hospital, 2-4-20, Ougi-Machi, Kita-ku, Osaka, 530-8480, Japan.
Yuri ItoDepartment of Medical Statistics, Research and Development Center, Osaka Medical and Pharmaceutical University, 2-7, Daigakumachi, Takatsuki, Osaka, 569-8686, Japan.
Tomio NakayamaCenter for Public Health Sciences, National Cancer Center, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Yumi OhtaOtorhinolryngology-Head and Neck Surgery, National Hospital Organization Osaka National Hospital, 2-1-14, Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan.
Eiji KobayashiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Oita University, 1-1 Idaigaoka Hasama-Machi, Yufu, Oita, 879-5593, Japan.
Kayo NakataCancer Control Center, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Toshitaka MorishimaCancer Control Center, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Isao MiyashiroCancer Control Center, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Yutaka UedaDepartment of Advanced Prevention and Health Sciences, Wakayama Medical University, 811-1, Kimiidera, Wakayama, Wakayama, 641-8509, Japan.

Funding

A Health and Labour Sciences Research Grant 23EA1002
6 · The paper itself

Abstract

The trends in cancers of Human papillomavirus (HPV)-related cancer sites in Japan are insufficiently reported. We evaluated the long-term trends of them as a baseline before the effects of HPV vaccine introduction became apparent in Japan. This retrospective, population-based study used data from the Osaka Cancer Registry to analyze 39,349 cases between 1977 and 2019. For women, the ASIRs were particularly high for cervical cancer. For squamous cell carcinoma, the ASIR changed from a decrease (from high to low) to an increase (from low to high) around 2000, although the trend for females aged 40-59 has recently showed no significant change. The trend in ASIR for adenocarcinoma also shifted from an increase to no significant change in the 40-59 age group, but increased consistently in the ≤ 39 age group. Vaginal cancer exhibited no significant change, while cancers of the oropharynx, anus, and vulva have increased. For men, cancers of the oropharynx and anus consistently increased. Squamous cell carcinoma of the anus decreased from 1997 to 2004, but then increased thereafter. Similarly, penile cancer decreased from 1977 to 1995, but then increased. Future studies will observe how this trend changes as groups with high HPV vaccination rates reach cancer-susceptible ages.

Indexed as

Human Papillomavirus VirusesPapillomavirus InfectionsAdenocarcinomaAdultAgedAge FactorsAnus NeoplasmsCarcinoma, Squamous CellFemaleHumansIncidenceJapanMaleMiddle AgedOropharyngeal NeoplasmsPapillomavirus VaccinesPapillomavirus VaccinesCancers of HPV-related cancer sitesCervical cancerHPV vaccineIncidenceJapanTrend

Identifiers

PMID42120649
PMCPMC13358142

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.