Evidence map›Paper›PMID 42120597›Full record

ArticleInternational journal of obesity (2005)2026

Butyrylcholinesterase as a potential biomarker of metabolic imbalances in Afro-descendant populations.

Denise Raquel de Moura Bones, Marcia Machado Ramos, Natali Fátima Veigand, Iriel Araceli Joerin-Luque, Natalie Mary Sukow, Sarah Elisabeth Cupertino, Priscila Ianzen Dos Santos, Hellen Karoline de Oliveira Nunes, Aymee Fernanda Gros, Victor Dobis Barros and 16 more

Abstract read
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In one paragraph

Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Denise Raquel de Moura BonesPrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil. denisebones@hotmail.com.ORCID http://orcid.org/0009-0000-8409-6801
Marcia Machado RamosPrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.ORCID http://orcid.org/0009-0008-0470-8571
Natali Fátima VeigandLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Iriel Araceli Joerin-LuquePrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Natalie Mary SukowPrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Sarah Elisabeth CupertinoPrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Priscila Ianzen Dos SantosLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Hellen Karoline de Oliveira NunesLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Aymee Fernanda GrosLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Victor Dobis BarrosLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Joana Gehlen TessaroLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.ORCID http://orcid.org/0000-0002-8797-112X
Luana Leonardo GarciaLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Isabela Dall Oglio BuccoLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Letícia Boslooper GonçalvesPrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Ana Cecília Guimarães AlvesPrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Thalia Roberta de MoraesLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Selma Árabe AndriettaLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Thomas Farias de CristoLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Vanessa Dos Santos Ribeiro ZanettePrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Adriana Inês de PaulaDepartamento de Educação Física, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Aline Borsato HauserLaboratório Escola de Análises Clínicas, Departamento de Farmácia, Universidade Federal do Paraná, Curitiba, Brazil.ORCID http://orcid.org/0000-0003-0514-9421
Claudemira Vieira Gusmão LopesCâmara de Educação do Campo, Universidade Federal do Paraná (UFPR), Setor Litoral, Matinhos, Brazil.
Luciane Viater TurekPrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Lupe Furtado AllePrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Ricardo Lehtonen Rodrigues SouzaPrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Marcia Holsbach BeltramePrograma de Pós-graduação em Genética, Departamento de Genética, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigated butyrylcholinesterase (BChE) activity and its genetic variants (-116, A, and K) in Afro-Brazilian individuals living in two African-derived communities (quilombos) in southern Brazil. Parameters, including obesity, glucose, and lipid profile, were compared with those of Euro-Brazilian individuals from the same region. The study aimed to characterize population parameters and assess their influence on factors involved in metabolic syndrome, obesity, and type 2 diabetes mellitus (TDM2).

methodsA total of 198 Afro-Brazilians and 114 Euro-Brazilians participated. BChE activity was measured using the Ellman method, and variants were genotyped by PCR-SSP. Statistical analyses included t-test or Mann-Whitney, ANOVA, chi-square or Fisher's exact test, correlations, and age- and sex-adjusted regression models.

resultsThe mean BChE activity in the Quilombola population was 3.71 U/mL and was significantly higher in people with TDM2 and/or obesity (p = 0.016), and associated with triglycerides, total cholesterol, overweight, and male sex. A significant interaction between triglycerides and glycated hemoglobin was observed (p = 0.016). BChE activity was higher in Quilombolas than in Euro-Brazilians, regardless of metabolic status, suggesting ethnic influence. BCHE gene variants (A, -116, and K) showed frequencies similar to other populations. Although enzymatic activity varied among haplotypes, differences were not statistically significant. These results highlight the relevance of clinical and ethnic factors in interpreting BChE activity.

conclusionsThis study revealed higher BChE activity and TDM2 prevalence in Afro-Brazilian populations compared to Euro-Brazilians, and these differences correlate with non-genetic factors. The BCHE genetic variants investigated showed no robust associations after correction for multiple testing, suggesting that their effects on metabolic traits may be subtle and context-dependent. This is the first study to quantify BChE activity in Afro-Brazilian Quilombola populations and the second in Black individuals in Brazil, highlighting the importance of considering genetic and ethnic factors in metabolic risk assessment.

Indexed as

Black PeopleButyrylcholinesteraseDiabetes Mellitus, Type 2Metabolic SyndromeObesityAdultAfrican PeopleBiomarkersBrazilFemaleGenotypeHumansMaleMiddle AgedWhite PeopleBiomarkersButyrylcholinesterase

Identifiers

PMID42120597
PMCPMC13461358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.