Evidence map›Paper›PMID 42120589›Full record

ArticleScientific reports2026

Antioxidant, pro-oxidant, cytotoxic and antimicrobial properties of selected plant phenolic compounds and resulting structure-activity relationships.

Monika Kalinowska, Ewelina Gołębiewska, Małgorzata Zawadzka, Elżbieta Wołejko, Agata Jabłońska-Trypuć, Urszula Wydro, Grzegorz Świderski, Renata Świsłocka, Waldemar Priebe, Włodzimierz Lewandowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Monika KalinowskaDepartment of Chemistry, Biology and Biotechnology, Institute of Civil Engineering and Energetics, Faculty of Civil Engineering and Environmental Science, Bialystok University of Technology, Wiejska 45E Street, Bialystok, 15-351, Poland. m.kalinowska@pb.edu.pl.
Ewelina GołębiewskaDepartment of Chemistry, Biology and Biotechnology, Institute of Civil Engineering and Energetics, Faculty of Civil Engineering and Environmental Science, Bialystok University of Technology, Wiejska 45E Street, Bialystok, 15-351, Poland.
Małgorzata ZawadzkaDepartment of Chemistry, Biology and Biotechnology, Institute of Civil Engineering and Energetics, Faculty of Civil Engineering and Environmental Science, Bialystok University of Technology, Wiejska 45E Street, Bialystok, 15-351, Poland.
Elżbieta WołejkoDepartment of Chemistry, Biology and Biotechnology, Institute of Civil Engineering and Energetics, Faculty of Civil Engineering and Environmental Science, Bialystok University of Technology, Wiejska 45E Street, Bialystok, 15-351, Poland.
Agata Jabłońska-TrypućDepartment of Chemistry, Biology and Biotechnology, Institute of Civil Engineering and Energetics, Faculty of Civil Engineering and Environmental Science, Bialystok University of Technology, Wiejska 45E Street, Bialystok, 15-351, Poland.
Urszula WydroDepartment of Chemistry, Biology and Biotechnology, Institute of Civil Engineering and Energetics, Faculty of Civil Engineering and Environmental Science, Bialystok University of Technology, Wiejska 45E Street, Bialystok, 15-351, Poland.
Grzegorz ŚwiderskiDepartment of Chemistry, Biology and Biotechnology, Institute of Civil Engineering and Energetics, Faculty of Civil Engineering and Environmental Science, Bialystok University of Technology, Wiejska 45E Street, Bialystok, 15-351, Poland.
Renata ŚwisłockaDepartment of Chemistry, Biology and Biotechnology, Institute of Civil Engineering and Energetics, Faculty of Civil Engineering and Environmental Science, Bialystok University of Technology, Wiejska 45E Street, Bialystok, 15-351, Poland.
Waldemar PriebeDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1901 East Rd., Houston, TX, 77054, USA.
Włodzimierz LewandowskiDepartment of Chemistry, Biology and Biotechnology, Institute of Civil Engineering and Energetics, Faculty of Civil Engineering and Environmental Science, Bialystok University of Technology, Wiejska 45E Street, Bialystok, 15-351, Poland.

Funding

Ministerstwo Edukacji i Nauki WZ/WB-IIŚ/3/2026Narodowe Centrum Nauki 2020/39/B/NZ9/01894
6 · The paper itself

Abstract

This study provides a comprehensive evaluation of the biological properties of six selected phenolic compounds: chlorogenic, caffeic, p-coumaric, rosmarinic, gallic and tannic acids. Their antioxidant potential was determined using DPPH, ABTS, FRAP, CUPRAC, lipid peroxidation inhibition and pro-oxidant assays, while antimicrobial activity was tested against Staphylococcus aureus and Candida albicans. In addition, cytotoxicity toward human skin melanoma A-375 cells and normal fibroblasts was examined, together with the assessment of intracellular ROS, GSH/GSSG ratio, thiol group content, and lipid peroxidation products. The results revealed clear structural dependence of biological activity, with the number and distribution of hydroxyl groups playing a decisive role. Tannic acid exhibited the strongest antioxidant and antimicrobial properties, while gallic and tannic acids showed the most pronounced cytotoxicity toward melanoma cells, accompanied by elevated oxidative stress and redox imbalance, with limited toxicity toward normal fibroblasts. These findings support the potential application of plant-derived phenolic compounds as natural agents with antioxidant, antimicrobial and anticancer activity, making them promising candidates for pharmaceutical and cosmetic use.

Indexed as

Anti-Infective AgentsAntioxidantsPhenolsPlant ExtractsCandida albicansCell Line, TumorFibroblastsGallic AcidHumansLipid PeroxidationMicrobial Sensitivity TestsOxidative StressReactive Oxygen SpeciesStaphylococcus aureusStructure-Activity RelationshipTanninsAnti-Infective AgentsAntioxidantsGallic AcidPhenolsPlant ExtractsReactive Oxygen SpeciesTanninsAntimicrobialAntioxidantCytotoxicGallic acidPhenolic compoundsPro-oxidantRosmarinic acidTannic acid

Identifiers

PMID42120589
PMCPMC13350958

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.