Evidence map›Paper›PMID 42120574›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Clinical-pathological T-stage discrepancy in OPHL: impact on oncologic outcomes.

Carlotta Liberale, Sara Librio, Edoardo Serafini, Rocco Strangio, Leonardo Roncadi, Sara Bassani, Giulia Querzoli, Francesco Mattioli, Daniele Marchioni, Livio Presutti and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carlotta LiberaleDepartment of Otolaryngology Head and Neck Surgery, University Hospital of Modena, Modena, Italy. carlotta.liberale@gmail.com.ORCID http://orcid.org/0000-0003-4285-6862
Sara LibrioAlma Mater Studiorum-Università di Bologna, Bologna, Italy.
Edoardo SerafiniDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Rocco StrangioDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Leonardo RoncadiDepartment of Otolaryngology Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Sara BassaniDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Giulia QuerzoliAlma Mater Studiorum-Università di Bologna, Bologna, Italy.
Francesco MattioliDepartment of Otolaryngology Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Daniele MarchioniDepartment of Otolaryngology Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Livio PresuttiDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Gabriele MolteniDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
Matteo FermiDepartment of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical-pathological discordance in T staging is common in laryngeal squamous cell carcinoma (LSCC) and may affect treatment planning and prognosis. Its impact in patients treated with open partial horizontal laryngectomy (OPHL) remains unclear.

methodsA retrospective multicenter study was conducted on 106 patients with glottic or supraglottic LSCC treated with OPHL. Discrepancies between clinical (cT) and pathological (pT) staging were analyzed. Associations with preoperative factors, adjuvant therapy, disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS) were evaluated.

resultsT-stage discordance was observed in 37.7% of patients, with 19.8% upstaged and 17.9% downstaged. No preoperative factor was significantly associated with discordance. T-stage discrepancy was not significantly associated with DFS, DSS, OS, or the need for adjuvant therapy.

conclusionIn patients undergoing OPHL, clinical-pathological T-stage discordance does not appear to significantly affect oncologic outcomes, likely due to the modular and adaptable nature of the surgical procedure.

Indexed as

Carcinoma, Squamous CellLaryngeal NeoplasmsLaryngectomyAgedAged, 80 and overDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesSurvival RateTreatment OutcomeDiscordanceLaryngeal squamous cell carcinomaOPHLOverstagingRecurrenceSurvivalTNM stagingUnderstaging

Identifiers

PMID42120574

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.