Evidence map›Paper›PMID 42120510›Full record

ArticleScientific reports2026

Divergent cell-type specific hypoxia responses in human stem cell-derived and primary islets.

Kameron Bradley, Camryn Moore, Matthew Ishahak, Marlie M Maestas, Daniel A Veronese-Paniagua, Jeffrey R Millman

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Kameron BradleyDivision of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Camryn MooreDivision of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Matthew IshahakDivision of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Marlie M MaestasDivision of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Daniel A Veronese-PaniaguaDivision of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08 660 South Euclid Avenue, St. Louis, MO, 63110, USA.
Jeffrey R MillmanDivision of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08 660 South Euclid Avenue, St. Louis, MO, 63110, USA. jmillman@wustl.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
DIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7M
Training Program in Cellular and Molecular BiologyT32GM139774 · NIGMS · WASHINGTON UNIVERSITY · PI HEATHER L TRUE-KROB · 2021 to 2026
$6.7M
STUDYING THE ROLE OF THE MICROENVIRONMENT ON DIFFERENTIATION AND MATURATION OF BETA CELLSR01DK114233 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Robert Millman · 2017 to 2026
$3.6M
MARC U-STAR PROGRAM AT WASHINGTON UNIVERSITY IN ST. LOUIST34GM083914 · NIGMS · WASHINGTON UNIVERSITY · PI SKEATH, JAMES BENJAMIN · 2009 to 2020
$2.3M
Breakthrough T1D (3-SRA-2023-1295-S-BNCI NIH HHS P30 CA091842NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK114233NIDDK NIH HHS T32 DK007120NIGMS NIH HHS T32 GM139774NIGMS NIH HHS T34 GM083914NIH HHS R01DK114233NIH HHS T32DK007120NIH HHS T32GM139774NIH HHS T34GM083914NSF DGE-2139839
6 · The paper itself

Abstract

The success of stem cell-derived islet (SC-islet) therapy for type 1 diabetes is limited by poor graft survival in the hypoxic post-transplantation microenvironment. While the response of SC-islets to chronic hypoxia has been studied, a direct comparison to primary human islets during the acute hypoxic phase has not been performed. Here, we conduct a comparative single-cell transcriptomic and functional analysis of human SC-islets and primary islets exposed to acute hypoxia (1% O

Indexed as

Islets of LangerhansStem CellsApoptosisCell HypoxiaCells, CulturedGene Expression ProfilingGlucoseHumansInsulinInsulin-Secreting CellsInsulin SecretionTranscriptomeGlucoseInsulinGlucose-stimulated insulin secretionHypoxiaIsletsSingle-cell RNA sequencingStem cellsType 1 diabetes

Identifiers

PMID42120510
PMCPMC13357543

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.