Evidence map›Paper›PMID 42120460›Full record

ArticleScientific reports2026

Multi-grader validation of the telemedicine retinopathy of prematurity severity score.

Harrison W Pratt, Sarthak V Shah, Cindy S Zhao, Arthur R Brant, Caroline R Baumal, Cagri G Besirli, Audina M Berrocal, Kimberley A Drenser, Anna L Ells, Clio Armitage Harper and 9 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Harrison W PrattDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Sarthak V ShahDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Cindy S ZhaoDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Arthur R BrantDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Caroline R BaumalDepartment of Ophthalmology, New England Eye Center, Tufts Medical Center, Boston, MA, USA.
Cagri G BesirliDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.
Audina M BerrocalDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Kimberley A DrenserDepartment of Ophthalmology, William Beaumont Hospital, Oakland University, Royal Oak, MI, USA.
Anna L EllsCalgary Retina Consultants, Calgary, AB, Canada.
Clio Armitage HarperAustin Retina Associates, Austin, TX, USA.
G Baker HubbardDepartment of Ophthalmology, Emory Eye Center, Emory University School of Medicine, Atlanta, GA, USA.
Eric D NudlemanDepartment of Ophthalmology, Shiley Eye Institute, University of California San Diego, San Diego, CA, USA.
Polly QuiramRetina Consultants of Minnesota, Edina, MN, USA.
Irena TsuiDepartment of Ophthalmology, Doheny Eye Institute and Stein Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.
Edward WoodAustin Retina Associates, Austin, TX, USA.
Yoshihiro YonekawaMid Atlantic Retina, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Tatiana RosenblattDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Jochen KummDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Darius M MoshfeghiDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, USA. dariusm@stanford.edu.

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
NEI NIH HHS NEI P30- EY026877NEI NIH HHS P30 EY026877
6 · The paper itself

Abstract

We aimed to statefully validate Retinopathy of Prematurity (ROP) grading by evaluating intergrader variability over age-matched simulated exams. In a prospective retinal photographic grading cohort study, both eyes of twenty patients with five images per eye per visit were graded by twelve expert graders across six weekly visits. For each eye visit, ROP experts graded the Zone, Stage, and Plus, from which the Telemedicine ROP Severity Score (tROP-SS) was calculated. Graders retained knowledge of prior assessments for a given eye and followed International Classification of ROP rules. Intergrader coefficient of variation (CoV) for Zone, Stage, Plus, and tROP-SS remained below 20% across six weeks of age-matched visits. Zone showed the most changes in CoV (p < 0.001) with a minimum at week three of 6.0% (95% CI: 3.0-8.9%). Stage (9.2-13.1%) did not significantly vary over time. CoV of Plus gradually increased (p = 0.002) from week 1 (1.2%, 95% CI: 0.3-2.0%) to week 6 (3.3%, 95% CI: 1.7-4.9%). Agreement for tROP-SS varied over time (p < 0.001) and reached a local minimum at week three (10.5%, 95% CI: 7.3-13.8%). High intergrader agreement in a stateful data set validates the use of tROP-SS as a scoring system to capture week-to-week ROP progression.

Indexed as

Retinopathy of PrematurityFemaleGestational AgeHumansInfant, NewbornMaleProspective StudiesSeverity of Illness IndexTelemedicine

Identifiers

PMID42120460
PMCPMC13357821

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.