Evidence map›Paper›PMID 42120427›Full record

ArticleNature communications2026

Intra-mitochondrial glycolysis maintains mitochondrial function and underlies the pathogenesis of retinitis pigmentosa.

Linghui Kong, Jiajian Liang, Dan Liu, Shanshan Jia, Hui Gu, Yiwen He, Wenting Luo, Songying Cao, Yizhang Dong, Chao Yang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Linghui KongNHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Jiajian LiangDepartment of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Dan LiuNHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Shanshan JiaNHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.ORCID http://orcid.org/0000-0001-8413-9891
Hui GuNHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Yiwen HeNHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Wenting LuoNHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Songying CaoNHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Yizhang DongNHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Chao YangNHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Minghui LiaoNational Engineering Research Center for Multimedia Software, School of Computer Science, Wuhan University, Wuhan, Hubei, China.
Guojia WanNational Engineering Research Center for Multimedia Software, School of Computer Science, Wuhan University, Wuhan, Hubei, China.
Bo DuNational Engineering Research Center for Multimedia Software, School of Computer Science, Wuhan University, Wuhan, Hubei, China.ORCID http://orcid.org/0000-0002-0059-8458
Dongxue Ding *NHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. dxding@cmu.edu.cn.ORCID http://orcid.org/0000-0003-0518-9810
Wei Ma *NHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. cmu92294183@126.com.ORCID http://orcid.org/0000-0002-7362-6261
Xiaowei Wei *NHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. weiweina20000513@163.com.ORCID http://orcid.org/0000-0003-2320-8982
Anhua Wu *NHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. ahwu@cmu.edu.cn.ORCID http://orcid.org/0000-0002-3402-1884
Zhengwei Yuan *NHC Key Laboratory of Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. yuanzw@hotmail.com.ORCID http://orcid.org/0000-0003-0967-9462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycolysis is classically defined as a cytoplasmic process. Here, in our investigation of mitochondrial dysfunction in Retinitis Pigmentosa (RP), we report the unexpected discovery of a complete and functional glycolytic pathway operating inside mitochondria. Through CoIP-MS, polysome profiling, and [U-

Indexed as

GlycolysisMitochondriaRetinitis PigmentosaAnimalsGlucoseHumansMembrane ProteinsMiceMice, KnockoutNADReactive Oxygen SpeciesZebrafishGlucoseMembrane ProteinsNADReactive Oxygen Species

Identifiers

PMID42120427
PMCPMC13376219

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.