Evidence map›Paper›PMID 42120408›Full record

ArticleNature communications2026

An end-to-end hybrid deep-learning approach for single-shot wavefront sensing and correction.

Sina Moayed Baharlou, Muhammad Waleed Khalid, Guli Gulinihali, Jeongho Ha, Liyi Hsu, Samantha C Lewis, Lei Tian, Yeshaiahu Fainman, Alexander V Sergienko, Abdoulaye Ndao

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sina Moayed Baharlou *Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0740-8570
Muhammad Waleed Khalid *Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0009-0003-9672-5494
Guli GulinihaliDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA.
Jeongho HaDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA.
Liyi HsuDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA.
Samantha C LewisDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-6306-443X
Lei TianDepartment of Electrical and Computer Engineering & Photonics Center, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1316-4456
Yeshaiahu FainmanDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA.
Alexander V SergienkoDepartment of Electrical and Computer Engineering & Photonics Center, Boston University, Boston, MA, USA.
Abdoulaye NdaoDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA. a1ndao@ucsd.edu.ORCID http://orcid.org/0009-0002-0593-8842

Funding

Systems analysis of mitochondrial genome maintenance in physiological contextR35GM147218 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Samantha C Lewis · 2022 to 2026
$2.1M
NIGMS NIH HHS R35 GM147218
6 · The paper itself

Abstract

Optical aberrations fundamentally limit the performance of optical systems across scales, from microscopy and astronomy to quantum imaging and ubiquitous technologies such as smartphone cameras, autonomous vehicles, and optical communication networks. Despite sustained progress in wavefront sensing and correction, existing approaches typically require multiple intensity measurements and iterative phase retrieval algorithms and are often restricted to narrowband operation and simple beam profiles. Their performance further degrades when aberrations are weak or obscured by noise. Here we report a single-shot wavefront sensing and correction paradigm that overcomes the limitations of existing approaches. Central to the approach is the integration of a learned optical phase mask that acts as a physical encoder and is jointly optimized with a neural-network decoder. This encoding removes intrinsic phase ambiguities and significantly enhances sensitivity to weak aberrations. By leveraging this hybrid deep-learning architecture, our method directly and unambiguously retrieves Zernike-based phase distortions from a single focal-plane intensity image, eliminating the need for defocus measurements, or iterative phase reconstruction. The framework is intrinsically broadband, exhibits strong robustness to noise, and generalizes across a diverse class of structured light fields. Together, these capabilities establish a scalable and practical foundation for real-time aberration correction in next-generation optical and photonic systems.

Identifiers

PMID42120408
PMCPMC13377082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.