Evidence map›Paper›PMID 42120368›Full record

ArticleNature communications2026

Whole-protein screening and multi-modal profiling of antigen-specific CD4

Rongyu Zhang, Jingqi Qi, Michaela McKasson, Jongchan Choi, Vanessa Gutierrez, Conor Brennan, Sunga Hong, William Chour, Rachel H Ng, Jingyi Xie and 30 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Rongyu ZhangInstitute for Systems Biology, Seattle, WA, USA.
Jingqi QiInstitute for Systems Biology, Seattle, WA, USA.
Michaela McKassonInstitute for Systems Biology, Seattle, WA, USA.
Jongchan ChoiInstitute for Systems Biology, Seattle, WA, USA.ORCID 0000-0003-0394-9978
Vanessa GutierrezInstitute for Systems Biology, Seattle, WA, USA.
Conor BrennanInstitute for Systems Biology, Seattle, WA, USA.
Sunga HongInstitute for Systems Biology, Seattle, WA, USA.ORCID 0000-0003-4412-2811
William ChourInstitute for Systems Biology, Seattle, WA, USA.ORCID 0000-0003-1817-0123
Rachel H NgInstitute for Systems Biology, Seattle, WA, USA.ORCID 0000-0003-3692-8524
Jingyi XieInstitute for Systems Biology, Seattle, WA, USA.
Dan YuanInstitute for Systems Biology, Seattle, WA, USA.
Andrew WebsterInstitute for Systems Biology, Seattle, WA, USA.
Simranjeet K SidhuInstitute for Systems Biology, Seattle, WA, USA.
Abby AndersonInstitute for Systems Biology, Seattle, WA, USA.
Daniel ChenInstitute for Systems Biology, Seattle, WA, USA.ORCID 0000-0001-6660-6257
Rick EdmarkInstitute for Systems Biology, Seattle, WA, USA.
Kim M MurrayInstitute for Systems Biology, Seattle, WA, USA.
Sarah LiInstitute for Systems Biology, Seattle, WA, USA.
Connor McDonaldInstitute for Systems Biology, Seattle, WA, USA.
Lee RowenInstitute for Systems Biology, Seattle, WA, USA.
Shuo WangInstitute for Systems Biology, Seattle, WA, USA.
Yusuf RasheedInstitute for Systems Biology, Seattle, WA, USA.
Yapeng SuInstitute for Systems Biology, Seattle, WA, USA.
Jamie R WagnerDepartment of Hematology & Hematopoietic Cell Transplantation (T Cell Therapeutics Research Laboratories), City of Hope Beckman Research Institute and Medical Center, Duarte, CA, USA.
Jia Ming ChenUniversity of California Los Angeles (UCLA), the Jonsson Comprehensive Cancer Center at UCLA, Parker Institute for Cancer Immunotherapy at UCLA, Los Angeles, CA, USA.ORCID 0000-0003-3992-9143
Karla NawalyUniversity of California Los Angeles (UCLA), the Jonsson Comprehensive Cancer Center at UCLA, Parker Institute for Cancer Immunotherapy at UCLA, Los Angeles, CA, USA.
Jie FuJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexandria DuvenSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, USA.
Stephen J FormanDepartment of Hematology & Hematopoietic Cell Transplantation (T Cell Therapeutics Research Laboratories), City of Hope Beckman Research Institute and Medical Center, Duarte, CA, USA.ORCID 0000-0002-2803-4152
Mihae SongDivision of Gynecologic Oncology, Department of Surgery, City of Hope, Duarte, CA, USA.ORCID 0000-0001-6457-6023
Saul J PricemanKSOM/Norris Center for Cancer Cellular Immunotherapy Research (CCCIR), Department of Medicine, Division of Medical Oncology, Keck School of Medicine of USC, Los Angeles, CA, USA.ORCID 0000-0002-8136-2112
Christine E BrownDepartment of Hematology & Hematopoietic Cell Transplantation (T Cell Therapeutics Research Laboratories), City of Hope Beckman Research Institute and Medical Center, Duarte, CA, USA.ORCID 0000-0003-4915-8207
Antoni RibasUniversity of California Los Angeles (UCLA), the Jonsson Comprehensive Cancer Center at UCLA, Parker Institute for Cancer Immunotherapy at UCLA, Los Angeles, CA, USA.ORCID 0000-0003-3669-8458
Deborah J WongUniversity of California Los Angeles (UCLA), the Jonsson Comprehensive Cancer Center at UCLA, Parker Institute for Cancer Immunotherapy at UCLA, Los Angeles, CA, USA.
Kelly G PaulsonPaul G. Allen Research Center, Providence-Swedish Cancer Institute, Seattle, WA, USA.
Charles W DrescherFred Hutchinson Cancer Center, Seattle, WA, USA.
Cristina Puig-SausUniversity of California Los Angeles (UCLA), the Jonsson Comprehensive Cancer Center at UCLA, Parker Institute for Cancer Immunotherapy at UCLA, Los Angeles, CA, USA.ORCID 0000-0002-3014-3649
Jason D GoldmanSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA, USA.ORCID 0000-0002-3825-6832
Cornelia L TrimbleJohns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-0397-5295
James R HeathInstitute for Systems Biology, Seattle, WA, USA. jheath@isbscience.org.ORCID 0000-0001-5356-4385

Funding

U.S. Department of Health & Human Services | National Institutes of Health (NIH) CA264090-01
6 · The paper itself

Abstract

Systematic whole-protein screening and comprehensive profiling of antigen-specific CD4

Indexed as

CD4-Positive T-LymphocytesSingle-Cell AnalysisAntigens, ViralCOVID-19Epitopes, T-LymphocyteFemaleHigh-Throughput Screening AssaysHumansOncogene Proteins, ViralReceptors, Antigen, T-Cell, alpha-betaSARS-CoV-2Spike Glycoprotein, CoronavirusAntigens, ViralEpitopes, T-LymphocyteOncogene Proteins, ViralReceptors, Antigen, T-Cell, alpha-betaSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID42120368
PMCPMC13168688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.