Evidence map›Paper›PMID 42120358›Full record

ArticleTranslational psychiatry2026

Fragmentomics features of cell free DNA in eating disorders.

Alisa Burova, Camille Verebi, Nicolas Lebrun, Juliette Nectoux, Audrey Boutonnet, Philibert Duriez, Philip Gorwood, Nicolas Ramoz, Thierry Bienvenu

Abstract read
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In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alisa Burova *Université de Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, « Genetic vulnerability to addictive and psychiatric disorders » team, Paris, France.
Camille Verebi *Université de Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, « Genetic vulnerability to addictive and psychiatric disorders » team, Paris, France.ORCID http://orcid.org/0000-0002-0524-4827
Nicolas LebrunUniversité de Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, « Genetic vulnerability to addictive and psychiatric disorders » team, Paris, France.ORCID http://orcid.org/0009-0006-8021-7454
Juliette NectouxService de Médecine Génomique des maladies de système et d'organe, Hôpital Cochin, Assistance Publique. Centre Université de Paris Cité, Paris, France.
Audrey BoutonnetTechnical Laboratory, ADELIS Tech, Labege, France.ORCID http://orcid.org/0009-0004-7837-6187
Philibert DuriezUniversité de Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, « Genetic vulnerability to addictive and psychiatric disorders » team, Paris, France.
Philip GorwoodUniversité de Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, « Genetic vulnerability to addictive and psychiatric disorders » team, Paris, France.
Nicolas RamozUniversité de Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, « Genetic vulnerability to addictive and psychiatric disorders » team, Paris, France.ORCID http://orcid.org/0000-0002-8070-9938
Thierry BienvenuUniversité de Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR1266, « Genetic vulnerability to addictive and psychiatric disorders » team, Paris, France. thierry.bienvenu@inserm.fr.ORCID http://orcid.org/0000-0002-5953-2728

Funding

Fondation de l'Avenir pour la Recherche Médicale Appliquée (Fondation de l'Avenir) AP_RM_22_004
6 · The paper itself

Abstract

Eating disorders are lacking reliable biomarkers despite their severe psychiatric and medical burden. In this study, we examined plasma cell-free DNA (cfDNA) from patients with the restrictive (ANR), or binge-purge (ANBP) subtypes of anorexia nervosa, as well as from those with bulimia nervosa (BN), and controls, using the BIABooster electrophoresis method and shallow whole-genome sequencing to characterize cfDNA fragmentomics. While absolute cfDNA concentrations did not differ between groups, patients exhibited consistent qualitative alterations. Patients with BN showed increased cfDNA at the first nucleosomal peak, while all patient groups displayed shifts towards shorter fragments in the second and third nucleosomal peaks. End-motif analysis revealed higher motif diversity and trinucleotide sequence motifs TNN-type enrichment in ANR, together with a lower ratio of trinucleotide sequence motifs CGN to NCG, which has been correlated with hypomethylation. Multivariate analyses demonstrated that ANBP exhibits a distinct molecular profile that is not explained by combined effects of anorexia and bulimia. These findings suggest that cfDNA in eating disorders carries biologically meaningful signatures related to chromatin organization, nuclease activity, and methylation. This supports the potential of cfDNA as a minimally invasive biomarker for the clinical management of eating disorders.

Indexed as

Anorexia NervosaBulimia NervosaCell-Free Nucleic AcidsFeeding and Eating DisordersAdultBiomarkersFemaleHumansWhole Genome SequencingYoung AdultBiomarkersCell-Free Nucleic Acids

Identifiers

PMID42120358
PMCPMC13338214

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.