ArticleAnalytical chemistry2026
Data-Driven Filter for Detector Oscillation Artifacts in Time-of-Flight Mass Spectrometry.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Time-of-flight mass spectrometry (TOF-MS) is widely used for complex mixture analysis due to its ability to detect thousands of chemical compounds in a single sample. However, high-intensity ions can saturate the detector and generate artifacts, commonly referred to as "detector ringing". These artifacts resemble true MS features and often persist after componentization, complicating data interpretation and feature prioritization. Here, we introduce a data-driven filtering approach that exploits the time-domain origin of detector ringing to remove such artifacts. Because ion flight times scale with
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