The transcriptional repressor PheR regulates uptake and catabolism of phenanthrene in Sphingobium sp. SHPJ-2.

Wanjing Wu, Wanxin Chen, Yuan Yang, Xu Qiu, Ping Xu, Hongzhi Tang, Weiwei Wang

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Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Wanjing WuState Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China.

Wanxin ChenState Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China.

Yuan YangState Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China.

Xu QiuState Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China.

Ping XuState Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China.

Hongzhi TangState Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China. Electronic address: tanghongzhi@sjtu.edu.cn.

Weiwei WangState Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China. Electronic address: oudigouzai@sjtu.edu.cn.

Funding

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6 · The paper itself

Abstract

Phenanthrene (PHE) is a typical polycyclic aromatic hydrocarbon (PAH) and a persistent pollutant. Aerobic catabolic metabolism of PHE involves the coordinated regulation between substrate uptake and the energy-intensive initial oxidation steps. Although Sphingobium sp. SHPJ-2 can efficiently degrade PHE, the mechanism linking PHE sensing to the activation of its catabolic pathway remains unclear. Here, we demonstrate that PheR, an IclR-family transcriptional repressor, links PHE availability to transcriptional activation of the phenanthrene-degradation operon in strain SHPJ-2. EMSA and DNase I footprinting analyses indicate that PheR specifically binds to P

Indexed as

Bacterial ProteinsPhenanthrenesRepressor ProteinsSphingomonadaceaeGene Expression Regulation, BacterialBacterial ProteinsphenanthrenePhenanthrenesRepressor ProteinsbiosensorsIclR-family transcriptional repressorphenanthrenepolycyclic aromatic hydrocarbonssphingomonads

Identifiers

PMID42119980

DOI10.1016/j.jbc.2026.113140

PMCPMC13273656

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.