Evidence map›Paper›PMID 42119924›Full record

ArticleMolecular & cellular proteomics : MCP2026

Region-Resolved Integrative Multi-Omic Characterization Reveals Diverse Tumor and Microenvironment Features of Pituitary Neuroendocrine Tumors.

Tao Xie, Qiang Xie, Qin Hu, Jiamin Hu, Yang Gao, Rongkui Luo, Chaolong Yan, Pin Chen, Zijiang Yang, Yi Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tao XieDepartment of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China; Cancer Center, Shanghai Zhongshan Hospital, Fudan University, Shanghai, China.
Qiang XieDepartment of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Qin HuDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiamin HuDepartment of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yang GaoDepartment of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Rongkui LuoDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Chaolong YanDepartment of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Pin ChenDepartment of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Zijiang YangDepartment of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yi LiuDepartment of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China.
George Takura TabengwaDepartment of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaobiao ZhangDepartment of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China; Cancer Center, Shanghai Zhongshan Hospital, Fudan University, Shanghai, China; Digital Medical Research Center, Fudan University, Shanghai, China. Electronic address: xiaobiao_zhang@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pituitary neuroendocrine tumors are frequently invasive, with cavernous sinus invasion leading to poor treatment outcomes and high recurrence. Regional differences within these tumors remain poorly understood, hindering targeted therapy development. Here, we present the first integrative multi-omics analysis combining proteomics, metabolomics and single-cell transcriptomics to characterize tumors from the cavernous sinus and saddle regions. Our results reveal profound regional and cellular heterogeneity: cavernous sinus tumors exhibit significantly enhanced cell proliferation, driven by cancer-associated fibroblasts through the IGF1-IGF1R-MAPK1 axis. Cancer-associated fibroblasts in the cavernous sinus secrete IGF1 under regulation of the transcription factor FOXO1, which binds to receptors on tumor cells to activate proliferation. Metabolomic profiling identifies proline as a key enriched metabolite that stimulates cancer-associated fibroblasts to produce collagen fibers, reinforcing a pro-tumorigenic microenvironment. Single-cell transcriptomics further delineates a distinct subpopulation of receptor-positive malignant cells and a high abundance of cancer-associated fibroblasts in the cavernous sinus. These findings establish core mechanisms underlying the aggressive behavior of cavernous sinus-invading tumors, providing novel actionable targets for precision therapeutic strategies tailored to distinct tumor regions.

Indexed as

Neuroendocrine TumorsPituitary NeoplasmsTumor MicroenvironmentAnimalsCancer-Associated FibroblastsCell ProliferationGene Expression Regulation, NeoplasticHumansMetabolomicsMultiomicsProteomicsCAFscavernous sinus regionmulti-omics researchPitNETssaddle region

Identifiers

PMID42119924
PMCPMC13279300

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.