Evidence map›Paper›PMID 42119903›Full record

ArticleJournal of affective disorders2026

Empathy profiles in posttraumatic stress disorder: A person-centered approach to understanding emotion dysregulation and psychopathology.

Xi Pan, Cori A Palermo, Milissa L Kaufman, George A Bonanno, Lauren A M Lebois

Abstract read
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xi PanMcLean Hospital, Belmont, MA, USA; Department of Counseling & Clinical Psychology, Columbia University Teachers College, New York, NY, USA.
Cori A PalermoMcLean Hospital, Belmont, MA, USA.
Milissa L KaufmanMcLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
George A BonannoDepartment of Counseling & Clinical Psychology, Columbia University Teachers College, New York, NY, USA.
Lauren A M LeboisMcLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: llebois@mclean.harvard.edu.

Funding

Multimodal Approaches to Neurobiology of Traumatic DissociationR01MH119227 · NIMH · MCLEAN HOSPITAL · PI KAUFMAN, MILISSA L · 2020 to 2024
$3.7M
Characterizing the Neurobiology of Pathological Dissociation: Mechanisms of Face Perception and Self Referential ProcessingK01MH118467 · NIMH · MCLEAN HOSPITAL · PI LEBOIS, LAUREN ANN MCDONOUGH · 2019 to 2022
$679k
NIMH NIH HHS K01 MH118467NIMH NIH HHS R01 MH119227
6 · The paper itself

Abstract

backgroundIndividuals with Posttraumatic stress disorder (PTSD) can experience significant emotion dysregulation and interpersonal impairments, with emerging evidence implicating alterations in empathy as a contributing factor. Prior research links specific empathy dimensions (e.g., personal distress, perspective taking) to psychopathology; however, little is known about how patterns across empathy dimensions may map onto distinct profiles, which in turn may be related to different clinical outcomes. The identification of empathy profiles in PTSD could provide the opportunity to tailor trauma interventions to specific patterns of empathic responding and improve interpersonal functioning. Therefore, this study aimed to identify empathy profiles in PTSD and their associations with emotion dysregulation and related clinical symptoms.

methodsParticipants were 108 adults with PTSD (77.8% female; mean age = 38.76) seeking trauma-focused treatment. K-means cluster analysis on the Interpersonal Reactivity Index empathy subscales identified empathy profiles. Linear models compared profiles on clinical measures (childhood trauma, depression, anxiety, PTSD symptoms, dissociation, emotion dysregulation).

resultsThree profiles emerged: High Empathy/Moderate Distress (32.4%), Moderate Empathy/Low Distress (38.0%), and Low Perspective-Taking/High Distress (29.6%). Follow-up univariate tests showed profiles differed significantly in depression, anxiety, and emotion dysregulation but not trauma history, PTSD symptoms, or dissociation. Emotion dysregulation differences remained significant after controlling for clinical and demographic covariates.

conclusionsWe identified novel empathy profiles in PTSD that show differential associations with emotion dysregulation and psychopathology. Emotion dysregulation emerged as the primary clinical correlate distinguishing these profiles, suggesting it may represent a key mechanism linking empathic patterns to functional outcomes.

Indexed as

Affective SymptomsEmotional RegulationEmpathyStress Disorders, Post-TraumaticAdultAnxietyCluster AnalysisDepressionFemaleHumansInterpersonal RelationsMaleMiddle AgedPsychopathologyEmotion dysregulationEmpathy profilesGender differencesPerson-centered approachPTSD

Identifiers

PMID42119903
PMCPMC13461235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.