ArticleThe American journal of pathology2026
SIRPα Cleavage Is Associated with Inflammatory Response, Corticosteroid Nonresponse, and Worse Prognosis in Clinical and Preclinical Models of Alcohol-Associated Hepatitis.
Article in The American journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Severe alcohol-associated hepatitis (sAH) has been associated with a high 30-day mortality rate. Corticosteroids are used in patients with sAH with limitations. There are no biomarkers measured upon hospitalization that predict responsiveness to corticosteroids. The role of signal regulatory protein (SIRP)-α, a receptor that regulates inflammation, has not been studied in patients with AH. In prospective test and validation cohorts of sAH patients treated with corticosteroids, plasma cytokines and SIRPα levels were measured. Studies in Sirpa
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