Evidence map›Paper›PMID 42119811›Full record

ArticleThe American journal of pathology2026

SIRPα Cleavage Is Associated with Inflammatory Response, Corticosteroid Nonresponse, and Worse Prognosis in Clinical and Preclinical Models of Alcohol-Associated Hepatitis.

Ethan R Steele, Dylan Nunn, David Malicote, Tyler C Gripshover, Rui S Treves, Nicolli Butzke-Souza, Jane Frimodig, Jon M Jacobs, Le Z Day, Timothy R Morgan and 17 more

Abstract read
In one paragraph

Article in The American journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Ethan R SteeleDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, Kentucky.
Dylan NunnDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, Kentucky.
David MalicoteDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, Kentucky.
Tyler C GripshoverDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky.
Rui S TrevesDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky.
Nicolli Butzke-SouzaDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky.
Jane FrimodigUniversity of Louisville Alcohol Research Center, University of Louisville School of Medicine, Louisville, Kentucky.
Jon M JacobsBiological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington.
Le Z DayBiological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington.
Timothy R MorganGastroenterology Section, VA Long Beach Healthcare System, Long Beach, California.
Aliya Asghar UddinGastroenterology Section, VA Long Beach Healthcare System, Long Beach, California.
Andrew StolzDivision of Gastrointestinal and Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Samer GawriehDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Wanzhu TuDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Suthat LiangpunsakulDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Srinivasan DasarathyDepartment of Transplant Hepatology, Hepatology, and Gastroenterology, Cleveland Clinic, Cleveland, Ohio.
Ramon BatallerLiver Unit, Hospital Clinic de Barcelona, Barcelona, Spain.
Gyongyi SzaboDepartment of Quantitative Health Sciences, Division of Biostatistics and Health Services, University of Massachusetts Chan Medical School, Worcester, Massachusetts.
Bruce A BartonDepartment of Quantitative Health Sciences, Division of Biostatistics and Health Services, University of Massachusetts Chan Medical School, Worcester, Massachusetts.
Vijay H ShahIntegrative Biology of Advanced Liver Disease Laboratory, Mayo Clinic, Rochester, Minnesota.
Arun J SanyalStravitz-Sanyal Institute for Liver Disease and Metabolic Health, Division of Gastroenterology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Mack C MitchellDivision of Internal Medicine-Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas.
Vatsalya VatsalyaUniversity of Louisville Alcohol Research Center, University of Louisville School of Medicine, Louisville, Kentucky.
Craig J McClainDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, Kentucky; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky; University of Louisville Alcohol Research Center, University of Louisville School of Medicine, Louisville, Kentucky.
Josiah E HardestyDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky; University of Louisville Alcohol Research Center, University of Louisville School of Medicine, Louisville, Kentucky. Electronic address: josiah.hardesty@louisville.edu.
Ashwani K SingalDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, Kentucky; University of Louisville Alcohol Research Center, University of Louisville School of Medicine, Louisville, Kentucky. Electronic address: ashwani.singal@louisville.edu.
AlcHepNet Investigators

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HOOD, JOSHUA L. · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
Novel Therapies for Alcoholic HepatitisU01AA021893 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI MCCLAIN, CRAIG J., MCCULLOUGH, ARTHUR JOSEPH · 2012 to 2017
$6.0M
Integrated therapies for alcohol use and ALD (ITAALD) Network -UofL Clinical CenterU01AA026980 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN, Ashwani K Singal · 2018 to 2026
$2.9M
Restoration and preservation of hepatic cardiolipin levels promotes liver regeneration in AHR00AA030627 · NIAAA · UNIVERSITY OF LOUISVILLE · PI Josiah E Hardesty · 2024 to 2026
$732k
NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R00 AA030627NIAAA NIH HHS U01 AA021893NIAAA NIH HHS U01 AA026980NIGMS NIH HHS P20 GM103436NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

Severe alcohol-associated hepatitis (sAH) has been associated with a high 30-day mortality rate. Corticosteroids are used in patients with sAH with limitations. There are no biomarkers measured upon hospitalization that predict responsiveness to corticosteroids. The role of signal regulatory protein (SIRP)-α, a receptor that regulates inflammation, has not been studied in patients with AH. In prospective test and validation cohorts of sAH patients treated with corticosteroids, plasma cytokines and SIRPα levels were measured. Studies in Sirpa

Indexed as

Adrenal Cortex HormonesAntigens, DifferentiationHepatitis, AlcoholicInflammationReceptors, ImmunologicAdultAnimalsBiomarkersCytokinesDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutAdrenal Cortex HormonesAntigens, DifferentiationBiomarkersCytokinesReceptors, ImmunologicSIRPA protein, humanSirpa protein, mouse

Identifiers

PMID42119811
PMCPMC13494214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.