ArticleCell calcium2026
Pseudomonas aeruginosa 3-oxo-C12HSL-induced apoptosis involves bitter taste receptor T2R14 and the mitochondrial calcium uniporter.
Article in Cell calcium, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Cigarette Smoke Exposure Attenuates T2R-Mediated Apoptosis in Head and Neck Squamous Cell Carcinoma.Head & neck · 2026Article
- Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells.International forum of allergy & rhinology · 2026Article
Corrections and comments
- Update of
Authors and funding
14 authors.
Funding
Abstract
Pseudomonas aeruginosa is an opportunistic pathogen that infects immunocompromised patients. P. aeruginosa infects airways in cystic fibrosis (CF) and chronic rhinosinusitis (CRS) and also infects oral and nasal epithelia in immunocompromised head and neck squamous cell carcinoma patients. P. aeruginosa produces several apoptosis-inducing factors, including N-3-oxo-dodecanoyl-L-homoserine lactone (3-oxo-C12HSL). Additionally, 3-oxo-C12HSL activates several human bitter taste G protein-coupled receptors (taste family 2 receptors, or T2Rs), including T2R14 expressed throughout the body. We previously discovered that activation of T2R14 causes apoptosis in either HNSCC cells or primary nasal cells cultured to reflect a squamous phenotype. While the conducting airways are normally a pseudostratified columnar epithelium, epithelial de-differentiation, squamous metaplasia, and enhanced apoptosis occur in both CF and CRS airways, often correlating with sites of P. aeruginosa colonization. We hypothesized that 3-oxo-C12HSL-induced apoptosis may involve T2R14. We found that 3-oxo-C12HSL activates sustained intracellular Ca
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