ArticleInternational journal of obstetric anesthesia2026
Antepartum mental health disorders and hypertensive disorders of pregnancy: a retrospective cohort study using the premier healthcare administrative database (2016-2020).
Article in International journal of obstetric anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundThe relationship between mental health disorders and hypertensive disorders of pregnancy is unclear. Our objective was to examine antepartum mental health disorders as risk factors for hypertensive disorders of pregnancy in a nationwide United States database.
methodsWe performed a retrospective cohort study using the Premier Healthcare Administrative Database in obstetric patients ≥18 years who delivered from 1/10/15 to 12/31/20. Exposures were antepartum (<20 weeks gestation) non-psychotic depressive, anxiety, and/or bipolar disorders ascertained by ICD-10 codes. Primary outcomes were hypertensive disorders (gestational hypertension, preeclampsia with and without severe features) diagnosed during birth hospitalization. A multivariable logistic regression model was used to examine associations of antepartum mental health disorders with hypertensive disorders adjusting for shared risk factors that were identified a priori.
results861,177 patients met inclusion criteria. Compared with an incidence of 13.1% of hypertensive disorders in patients without antepartum mental health disorders, patients with antepartum mental health disorders had increased odds of having a hypertensive disorder: depressive disorders (incidence 17.1%, adjusted odds ratio (aOR) 1.06, 95% confidence interval (CI) 1.03-1.09, E-value 1.21); anxiety (incidence 15.9%, aOR 1.22, CI 1.19-1.25, E-value 1.67); both depressive and anxiety disorders (incidence 18.2%, aOR 1.19, CI 1.16-1.23, E-value 1.59); bipolar disorders (incidence 16.8%, aOR 1.09, CI 1.04-1.15, E-value 1.24).
conclusionsAntepartum mood and anxiety disorders were associated with increased odds of hypertensive disorders, with anxiety conferring the highest odds. Our study highlights mental health disorders, particularly anxiety, as potential modifiable contributors to hypertensive disorders, offering an important yet underrecognized opportunity for intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.