Evidence map›Paper›PMID 42119200›Full record

ArticleThe Science of the total environment2026

Prenatal and childhood exposure to common plasticizers in relation to emotional and behavioral development through adolescence.

Lilly Meerts, Hanan El Marroun, Yuchan Mou, Mengling Liu, Leonardo Trasande, Henning Tiemeier, Kurunthachalam Kannan, Vincent W V Jaddoe, Tonya White, Akhgar Ghassabian

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In one paragraph

Article in The Science of the total environment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Lilly MeertsDepartment of Child and Adolescent Psychiatry, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands.
Hanan El MarrounDepartment of Child and Adolescent Psychiatry, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioral Sciences, Rotterdam, the Netherlands. Electronic address: h.marrounel@erasmusmc.nl.
Yuchan MouDepartment of Child and Adolescent Psychiatry, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands.
Mengling LiuDepartment of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Leonardo TrasandeDepartment of Population Health, NYU Grossman School of Medicine, New York, NY, USA; Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA.
Henning TiemeierDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Kurunthachalam KannanDepartment of Environmental Health Sciences, College of Integrated Health Sciences, State University of New York at Albany, New York, NY, USA; Wadsworth Center, New York State Department of Health, Albany, New York, NY, USA.
Vincent W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands.
Tonya WhiteSection on Social and Cognitive Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD, USA.
Akhgar GhassabianDepartment of Population Health, NYU Grossman School of Medicine, New York, NY, USA; Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
Brain Influences of Phthalates and Bisphenols in AdolescentsR01ES032826 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian · 2021 to 2026
$2.8M
NIEHS NIH HHS R01 ES032826NIH HHS UH3 OD023305
6 · The paper itself

Abstract

backgroundIndividuals are ubiquitously exposed to bisphenols and phthalates, common plasticizers that may affect neurodevelopment. We examined associations of prenatal and childhood bisphenol and phthalate exposure with internalizing and externalizing problems from early childhood through adolescence.

methodsWithin the Generation R study, prenatal urinary concentrations of bisphenol A (BPA) and phthalate metabolites were assessed in early, mid- and late pregnancy and in childhood at age 6 years. Pregnancy levels were averaged and used in analyses. Internalizing and externalizing problems were reported by parents at child age 3, 6, 10 and 14 years and by children at ages 10 and 14 years. Mother-child dyads with at least one prenatal exposure measure and one internalizing or externalizing problem score during follow-up were included (n = 1361). Among children with childhood exposure measures, n = 651 had at least one internalizing or externalizing problem score. Associations were examined using linear mixed models. Mixture analysis was performed for self-reported scores at age 14 with G-computation.

findingsAssociations between phthalate/bisphenol levels and child outcomes were largely null. Except, prenatal mono-n-butylphthalate and mono-(2-ethyl-5-hydroxyhexyl)phthalate were associated with higher self-reported internalizing problem scores in girls (B

conclusionsAssociations of BPA and phthalate exposure with internalizing and externalizing problem scores in adolescents were largely null, associations with childhood phthalate exposure were less consistent and harder to interpret.

Indexed as

Environmental ExposureEnvironmental PollutantsMaternal ExposurePhthalic AcidsPlasticizersPrenatal Exposure Delayed EffectsAdolescentBenzhydryl CompoundsBisphenol A CompoundsBisphenolsChildChild, PreschoolEmotionsFemaleHumansMaleBenzhydryl Compoundsbisphenol ABisphenol A CompoundsBisphenolsEnvironmental PollutantsPhenolsphthalic acidPhthalic AcidsPlasticizersBehaviorBisphenolChild mental healthEmotionsEndocrine disruptorsEnvironmental exposurePhthalates

Identifiers

PMID42119200
PMCPMC13320848

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.