Trial reportDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus2026
Are age, comorbidity, and frailty associated with complications after minimally invasive esophagectomy? A multicenter cohort study.
Trial report in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerioperative risks in older, comorbid, and frail patients undergoing open esophagectomy are increased, whereas these risks remain uncertain for minimally invasive esophagectomy (MIE). This study investigates the relationship between age, comorbidity, frailty, and complications after MIE.
methodsProspective data from the randomized ICAN trial were used, which compared intrathoracic and cervical anastomosis in adult esophageal cancer patients undergoing MIE. Patients were categorized by age (<75 and ≥ 75 years), comorbidity (ASA, Charlson Comorbidity index (CCI), Cumulative Illness Rating Scale for Geriatrics (CIRS-G)), and frailty (TOPICS-MDS ≥0.20). Primary outcome: severe complications (Clavien-Dindo grade ≥ 3a). Secondary outcomes: overall complications, hospital and intensive care unit (ICU) length of stay (LOS), and hospital readmission. Multivariable regression analysis adjusted for gender and anastomosis location.
resultsAmong 245 patients, 87 (35.5%) had severe complications. Eighteen (7.3%) were aged ≥75 years, 49 (20%) had ASA ≥3, 41 (16.7%) had CCI ≥2, median CIRS-G score was 3 (IQR 2.0), and 14 patients (5.7%) were frail. In multivariable regression, age, ASA ≥3, CCI ≥2, and CIRS-G were not independently associated with severe complications, overall complications, readmission, hospital or ICU LOS. Multivariable regression analysis for frailty was limited by the small number of frail patients.
conclusionsOlder and comorbid patients did not experience higher rates of severe complications following MIE, suggesting that they may be considered safe candidates for MIE despite their age. When selected according to current clinical practice, age, and comorbidity alone should not rule out surgical consideration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.