ArticlePLoS neglected tropical diseases2026
Transmission potential of Culex and Aedes species for Madariaga virus, a member of the eastern equine encephalitis virus complex.
Article in PLoS neglected tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Evaluation of mosquito transmission of equine hepacivirus in laboratory and field studies.Journal of medical entomology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Madariaga virus (MADV), widely distributed in Latin America, can cause severe disease in humans and equids, yet key aspects of its transmission cycle remain unclear. To identify mosquitoes that could act as vectors of MADV, we assessed the vector competence of Aedes aegypti, Ae. albopictus, Ae. taeniorhynchus, Culex tarsalis, Cx. coronator, and Cx. quinquefasciatus, following oral exposure to MADV isolated in Panama (all species) or Brazil (Ae. taeniorhynchus only). We also evaluated temporal infection dynamics of MADV from Panama in Ae. aegypti and Ae. albopictus. MADV RNA and infectious virus were quantified in mosquito bodies, legs, and saliva. At 14 days post-exposure, five of the six species tested had virus detected in all biological sample types, indicating their potential to become infected with and transmit MADV. Conversely, Cx. quinquefasciatus was susceptible to midgut infection and dissemination but had no positive saliva samples, suggesting limited transmission potential. Aedes taeniorhynchus showed higher infection probabilities with MADV from Brazil compared with MADV from Panama. Time-course analysis revealed distinct infection dynamics in Ae. aegypti and Ae. albopictus, with infection increasing over time in Ae. aegypti, but peaking at 7 days post-exposure and then gradually declining in Ae. albopictus. Our findings indicate that MADV may be compatible with multiple mosquito species with broad geographic distributions, reinforce the need to investigate species- and strain-specific mosquito-virus interactions and their influence on arbovirus transmission dynamics, and support a potential role for Ae. taeniorhynchus as an amplification and bridge vector in endemic regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.