Observational studyCancer control : journal of the Moffitt Cancer Center
The Prognosis of Patients With Large Cell Carcinoma of the Cervix: A Retrospective Study of the SEER Database and a Chinese Multi-Center Registry.
Observational study in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IntroductionLarge cell neuroendocrine carcinoma of the cervix (LCNEC), a rare and aggressive malignancy, has poor survival. Due to the scarcity of specific treatment guidelines and the limitations of small retrospective studies, this study aims to assess prognostic factors and treatment outcomes in cervical LCNEC using data from both the SEER database and a Chinese multicenter registry.MethodsThis retrospective multicenter cohort study included 130 patients diagnosed with cervical LCNEC between 2004 and 2021, including 87 from the SEER database and 43 from the Chinese registry. We compared clinicopathological variables, treatment approaches such as surgery, chemotherapy, radiotherapy and survival outcomes. Kaplan-Meier and Cox regression analyses were employed to identify prognostic factors.ResultsThe Chinese cohort exhibited a lower proportion of metastatic cases (13.95% compared to 49.43%, p<0.001), earlier disease stages (AJCC IV: 13.95% vs. 49.43%, p<0.001), and higher rates of surgery (76.74% vs. 56.32%, p=0.023) and chemotherapy (93.02% vs. 83.91%, p=0.147). The median overall survival was 22.0 months (95% CI: 17.0-29.5), with the Chinese cohort demonstrating superior 5-year survival (44.0% vs. 27.3%, p<0.001). Surgery was found to reduce the risk of mortality in both cohorts, particularly for locally advanced disease. Chemotherapy improved survival in the SEER cohort, while radiotherapy showed no significant benefit. Advanced T-stage and nodal involvement were identified as predictors of poor prognosis.ConclusionSurgery and chemotherapy remain cornerstone interventions for survival improvement, with surgical resection showing particularly pronounced benefits in locally advanced cases. Prospective studies are needed to optimize guidelines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.