GuidelineClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Morphological and molecular characterization of epithelial ovarian cancer: SEOM-SEAP consensus guidelines for biomarker integration in clinical practice.
Guideline in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Epithelial ovarian cancer (OC) is the second leading cause of death among gynecologic malignancies and exhibits marked histological and molecular heterogeneity. Advances in tumor biology and targeted therapies have increased the need for accurate biomarker characterization. This updated consensus by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) reviews key morphological and molecular features for diagnosis and providing recommendations for biomarker assessment across major OC subtypes. The document addresses classical serum biomarkers, prognostic tools, and genomic alterations with therapeutic implications, including homologous recombination deficiency (HRD), BRCA1 and BRCA2 mutations, mismatch repair status, as well as other established and emerging biomarkers. Emphasis is placed on optimal sample selection, validated techniques, and multidisciplinary integration is required to ensure diagnostic quality. These recommendations aim to optimize prognostic stratification and guide personalized treatment strategies, ultimately improving clinical outcomes in ovarian cancer.
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