Evidence map›Paper›PMID 42118475›Full record

ArticleGeroScience2026

Construct validation of the vitality capacity domains 'energy and metabolism' and 'neuromuscular function' in relation to locomotor capacity and quality of life in community-dwelling middle-aged and older adults.

Francis Louter, Veerle Knoop, Jeroen Demarteau, Liza De Dobbeleer, David Beckwee, Siddhartha Lieten, Aziz Debain, Ellen Gorus, Sabrina Chettouf, Dax Houtkamp and 6 more

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Francis LouterFrailty & Resilience in Ageing Research Unit (FRIA), Vitality Research Group, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium.
Veerle KnoopFrailty & Resilience in Ageing Research Unit (FRIA), Vitality Research Group, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium.
Jeroen DemarteauFrailty & Resilience in Ageing Research Unit (FRIA), Vitality Research Group, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium.
Liza De DobbeleerFrailty & Resilience in Ageing Research Unit (FRIA), Vitality Research Group, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium.
David BeckweeSOMT University of Physiotherapy, Amersfoort, The Netherlands.
Siddhartha LietenFrailty & Resilience in Ageing Research Unit (FRIA), Vitality Research Group, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium.
Aziz DebainFrailty & Resilience in Ageing Research Unit (FRIA), Vitality Research Group, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium.
Ellen GorusFrailty & Resilience in Ageing Research Unit (FRIA), Vitality Research Group, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium.
Sabrina ChettoufSOMT University of Physiotherapy, Amersfoort, The Netherlands.
Dax HoutkampSOMT University of Physiotherapy, Amersfoort, The Netherlands.
Bart C BongersSOMT University of Physiotherapy, Amersfoort, The Netherlands.
Albert Van De WielSOMT University of Physiotherapy, Amersfoort, The Netherlands.
Gina RossiPersonality and Psychopathology Research Group (PEPS), Department of Psychology, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Bart JansenDepartment of Electronics and Informatics (ETRO), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Annelies Pool-GoudzwaardSOMT University of Physiotherapy, Amersfoort, The Netherlands.
Ivan BautmansFrailty & Resilience in Ageing Research Unit (FRIA), Vitality Research Group, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium. ivan.bautmans@vub.be.ORCID http://orcid.org/0000-0002-6820-9586

Funding

Vrije Universiteit Brussel IRP12Vrije Universiteit Brussel IRP22Vrije Universiteit Brussel IRP3
6 · The paper itself

Abstract

Vitality capacity (VC) reflects a physiological state and is a determinant domain of intrinsic capacity but has so far remained mainly theoretical. This study validates the vitality capacity domains 'energy and metabolism' and 'neuromuscular function' and examines its link to locomotor capacity and quality of life (QoL). Exploratory factor analysis (EFA) was performed on the combined dataset from the Fatigue Resistance AMErsfoort study (FRAME, n = 1000) and the Fatigue Plot study (FATPLOT,n = 620). Confirmatory factor analyses (CFA) were subsequently performed on data from the AMersfoort COhort study on functional decline, Healthy aging and Frailty (AMCOHF,n = 367) and the BrUssels sTudy on The Early pRedictors of FraiLtY (BUTTERFLY,n = 491), to validate VC in both middle-aged and older adults. Linear hierarchical regression analysis was used to investigate the relationship between VC, locomotor capacity, and QoL. EFA indicated a one-factor model and CFA validated this with good model fit in the dataset (BUTTERFLY) (Robust CFI; 0.960, SRMR: 0.040) and (AMCOHF) (Robust CFI; 0.942, SRMR: 0.055). This model validated maximal grip strength (GSmax), 30-s chair stand test (30CST), Multidimensional Fatigue Inventory (MFI-20) and Capacity to Perceived Vitality ratio physical (CPV-physical) to measure VC. Several assessments show a significant relationship with locomotor capacity and QoL. This study indicated that VC is a coherent domain and has a relationship with locomotor capacity and QoL.

Indexed as

FatigabilityHealthy ageingIntrinsic capacityNeuromuscular functionVitality capacity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.