Evidence map›Paper›PMID 42118469›Full record

ArticleAMB Express2026

Antibiotic resistance among Gram-negative bacteria in bloodstream infections in Shiraz, Iran (2012-2023).

Mohammad Hossein Nejati Boor Boor, Sahar Sabour, Hadi Ghasemi, Neda Mohagheghzadeh, Hossein Safari, Fatemeh Toranjzard, Zahra Esfandiari, Kosar Choopan, Shiva Nazari, Saeed Soleiman Meigooni and 1 more

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Article in AMB Express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Mohammad Hossein Nejati Boor BoorDoctor of Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Sahar SabourDepartment of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Hadi GhasemiHIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Neda MohagheghzadehDepartment of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Hossein SafariHealth Promotion Research Center, Iran University of Medical Sciences, Tehran, Iran.
Fatemeh ToranjzardDoctor of Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Zahra EsfandiariDoctor of Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Kosar ChoopanDoctor of Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiva NazariPediatric Congenital Hematologic Disorders Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saeed Soleiman MeigooniInfectious Diseases Research Centre, Aja University of Medical Sciences, Tehran, Iran.
Taher AzimiDepartment of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Taherazimi5@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular monitoring and conducting surveillance studies are necessary to control and treat antibiotic-resistant infections on a global scale. The present study aimed to perform a time-trend analysis of the distribution and antibiotic resistance of Gram-negative bacteria (GNB) isolated from bloodstream infections over 12 years in Iran. Throughout a 12-year duration, from January 2012 until the end of December 2023, data from the blood specimens of patients were obtained from three university teaching hospitals in Shiraz, Iran. Antimicrobial susceptibility profiles of GNB were determined using the Kirby-Bauer disk diffusion method (DDM) on Mueller-Hinton agar (MHA) media. A total of 391,762 blood samples were obtained from patients. Among these, 40,397 (10.31%) were confirmed to be positive for GNB. The frequency of GNB was higher among patients aged over 50 years. The highest number of GNB was isolated from the emergency (50.54%) ward. Escherichia coli with 42.65%, and Klebsiella spp. with 17.02% frequently isolated from blood specimens. CAZ was the most effective antimicrobial agent against Pseudomonas aeruginosa (7.16%), Acinetobacter spp. (1.18%), E. coli and Klebsiella spp. (1.17%). The trends observed in antibiotic resistance among GNB from 2012 to 2023 indicate a reduction in resistance levels for certain antibiotics: SXT decreased from 75.41 to 58.85%, TET from 82.39 to 25%, CAZ from 85.21 to 42.86%, AMP from 92.14 to 62.5%, and FEP from 100 to 67.96%. Results demonstrate a general downward trend in antibiotic resistance among GNB. However, variation in antibiotic resistance profile among GNB suggested that follow-up antimicrobial resistance (AMR) programs, along with constant screening and developing antimicrobial stewardship programs in Shiraz, are necessary.

Indexed as

Antibiotic resistanceEpidemiologyEscherichia coliGram-negative bacteriaPseudomonas aeruginosa

Identifiers

PMID42118469
PMCPMC13341989

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