Observational studyInternal and emergency medicine2026
Prescribing cascades among hospitalized older adults: a retrospective cohort study from the REPOSI registry.
Observational study in Internal and emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A prescribing cascade occurs when an adverse drug reaction (ADR) generated from an index drug (Drug A) is mistaken for a new medical condition that is in turn managed with a new drug prescription (Drug B). Prescribing cascades represent a factor influencing inappropriate prescribing and unnecessary polypharmacy, especially among older adults. Using the REPOSI registry, we conduct a retrospective observational study to examine the prevalence of potential prescribing cascades, as identified in the ThinkCascades framework, among patients aged ≥ 65 years admitted to geriatric or internal medicine wards. Evaluation was made at (i) admission, (ii) discharge, and (iii) at the 3 month follow-up. At admission the prescribing cascade was defined as "not-determined" owing to the unavailability of sequential prescription information, while at discharge or 3 month follow-up the cascade was defined as "introduced" when the marker medication (Drug B) was prescribed after the index medication (Drug A). At admission, among the REPOSI population of 10,253 hospitalized patients, 13.0% of them (1,335 cases) showed at least one "not-determined" prescribing cascade, with major prevalence for calcium channel blockers (CCBs) combined with diuretics (n = 932, 65.6%). During hospitalization, a total of 305 potential prescribing cascades were introduced, but 474 not-determined cascades were deprescribed at discharge. Three months after discharge, 31 new cases of potential prescribing cascades were introduced. For four out of nine prescribing cascades, low or no cases were found in all three situations. The proportion of patients exposed to potentially inappropriate prescribing cascades was relatively low. However, these findings highlight the need for practical tools to support physicians in preventing inappropriate prescribing.
Indexed as
Identifiers
42118390What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.