Evidence map›Paper›PMID 42118301›Full record

ArticleSurgery today2026

Outcomes and prognostic factors for sleeve lobectomy in patients with locally advanced non-small cell lung cancer.

Takamasa Fukui, Yojiro Yutaka, Zixuan Yao, Ichiro Sakanoue, Hidenao Kayawake, Ryota Sumitomo, Shigeto Nishikawa, Satona Tanaka, Daisuke Nakajima, Toshi Menju and 2 more

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Takamasa FukuiDepartment of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yojiro YutakaDepartment of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. yutaka7@kuhp.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0003-4220-969X
Zixuan YaoDepartment of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ichiro SakanoueDepartment of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hidenao KayawakeDepartment of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ryota SumitomoDepartment of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Shigeto NishikawaDepartment of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Satona TanakaDepartment of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Daisuke NakajimaDepartment of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Toshi MenjuDepartment of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yu HidakaDepartment of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hiroshi DateDepartment of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the safety and efficacy of sleeve lobectomy for patients with non-small cell lung cancer (NSCLC) and assess the prognostic impact of preoperative chemoradiotherapy.

methodsThe subjects of this retrospective study were 103 consecutive patients who underwent sleeve lobectomy at our institution between 2006 and 2021.

resultsSixty patients had squamous cell carcinoma (Sq), 33 had adenocarcinoma (Ad), and 10 had other types of NSCLC. Four anastomotic complications occurred, but there was no perioperative mortality. Downstaging was observed after preoperative treatment in 74% of 19 patients with Sq, and 56% of 9 patients with Ad. The pathologic response was greater in the patients with Sq than in those with Ad (- 91% vs. -32%). The 5-year overall survival (OS) and disease-free survival (DFS) rates were 62.3% and 58.1%, respectively. The patients with Sq had better DFS (73.5% vs. 21.6%) and OS (70.5% vs. 46.7%) than those with Ad. Multivariate analysis identified Ad histology (HR, 3.042; p = 0.0026) as a prognostic factor for DFS, and incomplete resection (HR, 2.940; p = 0.048) as a prognostic factor for OS. Among the 39 patients with recurrence, distant metastases were more frequent in those with Ad (72.7%) than in those with Sq (33.3%).

conclusionSleeve lobectomy is safe and effective for locally advanced NSCLC. Preoperative chemoradiotherapy was more effective for patients with locally advanced Sq than for those with Ad.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsPneumonectomyAgedChemoradiotherapyDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesSurvival RateTreatment OutcomeLocally advanced lung cancerNon-small cell lung cancerPreoperative chemoradiationSleeve lobectomy

Identifiers

PMID42118301

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