Evidence map›Paper›PMID 42118261›Full record

ArticleBioprocess and biosystems engineering2026

Genome-scale metabolic model guided metabolic flux analysis in the endophyte Alternaria burnsii NCIM1409.

Divya Dharshini Uma Shankar, Sarayu Murali, Shagun Shagun, Shyam Kumar Masakapalli, Karthik Raman, Smita Srivastava

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Article in Bioprocess and biosystems engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Divya Dharshini Uma Shankar *Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.
Sarayu Murali *Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.
Shagun ShagunSchool of Biosciences and Bioengineering, Indian Institute of Technology Mandi, Kamand, 175075, India.
Shyam Kumar MasakapalliSchool of Biosciences and Bioengineering, Indian Institute of Technology Mandi, Kamand, 175075, India.
Karthik RamanCentre for Integrative Biology and Systems Medicine (IBSE), Wadhwani School of Data Science and AI (WSAI), IIT Madras, Chennai, 600 036, India.
Smita SrivastavaDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India. smita@zmail.iitm.ac.in.

Funding

Higher Education Financing Agency CR24250381BTHEFA008458
6 · The paper itself

Abstract

Camptothecin (CPT), a monoterpene indole alkaloid widely used in anticancer therapy, faces production bottlenecks arising from its plant-based origin. In this study, we systematically investigated the metabolic network of the camptothecin-producing fungal endophyte Alternaria burnsii NCIM1409 using an integrative framework combining genome-scale metabolic modeling and

Indexed as

AlternariaCamptothecinEndophytesGenome, FungalMetabolic Flux AnalysisModels, BiologicalMetabolic Networks and PathwaysCamptothecin13C tracer analysisCamptothecinGenome-scale metabolic modellingSecondary metabolite

Identifiers

PMID42118261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.