Evidence map›Paper›PMID 42118234›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Wireless, Deep-Seeing Smart Pill: A NIR-II Fluorescence Imaging Capsule Endoscope for Gastrointestinal Cancer.

Weicheng Wang, Jinlei Jiang, Zhengting Wang, Shuqi Liu, Wei Wang, Xi Chen, Qirui Zhao, Xinyuan Cui, Cheng Zhou, Shengsheng Cui and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weicheng WangSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, P. R. China.
Jinlei JiangSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, P. R. China.
Zhengting WangDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China.ORCID https://orcid.org/0000-0001-5533-5711
Shuqi LiuGlobal Institute of Future Technology, Shanghai Jiao Tong University, Shanghai, P. R. China.
Wei WangSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0002-1293-9168
Xi ChenDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China.
Qirui ZhaoMedical and Engineering Cross Research Institute, the First Affiliated Hospital of Henan University, Kaifeng, P. R. China.ORCID https://orcid.org/0009-0005-1630-3924
Xinyuan CuiDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Cheng ZhouSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, P. R. China.
Shengsheng CuiSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, P. R. China.
Daxiang CuiSchool of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, P. R. China.

Funding

China Postdoctoral Science Foundation under Grant No.2025M781970，Q.Z.Henan Province Zhongyuan Scholar Talent Program No.264000510010，D.C.Henan Provincial Medical Science and Technology Research Plan -Major Provincial-Ministerial Jointly Funded Project SBGJ202501009Innovation Group Project of National Natural Science Foundation of China 81921002National Key Research and Development Program of China 2017FYA0205301Natural Science Foundation of Shanghai 22ZR1467600Project of International Cooperation and Exchanges of the National Natural Science Foundation of China 82020108017Projects of Shanghai Science and Technology Commission 20142201300Projects of Shanghai Science and Technology Commission 21DZ2203200
6 · The paper itself

Abstract

Gastrointestinal cancer detection technologies are evolving; capsule endoscopy (CE) overcomes the invasiveness of tethered endoscopes. However, current CEs exhibit limited penetration depth and low SNR due to strong photon scattering, absorption, and autofluorescence in biological tissues, potentially resulting in missed deep or small lesions. This study reports a near-infrared-II fluorescent imaging capsule endoscope (NIR-II FICE), a "smart pill" designed for early gastrointestinal cancer diagnosis. NIR-II FICE can detect NIR-II-specific fluorescence signals above 900 nm from lesional tissues using the NIR-II fluorescent nanoprobe (FNP). It possesses the advantages of high sensitivity, high resolution, strong tissue penetration ability, high SNR, and high-contrast imaging. Experiments show NIR‑II FICE can detect FNP at concentrations as low as 5 µg mL

Indexed as

Capsule EndoscopesCapsule EndoscopyGastrointestinal NeoplasmsOptical ImagingAnimalsHumansMiceSwinecapsule endoscopydual‐mode imagingearly gastrointestinal cancerfluorescent nanoprobenear‐infrared‐II fluorescent

Identifiers

PMID42118234
PMCPMC13335670

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.