ReviewCancer metastasis reviews2026
The role of iron in driving sex-biased differences in cancer.
Review in Cancer metastasis reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
2 authors.
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Abstract
Sex is a critical determining factor in cancer incidence, pathogenesis, and outcome. These effects result from sexual differentiation influencing mechanisms that regulate both normal and cancer biology. Iron biology is sexually dimorphic in nature and plays a key role in tumorigenesis. Therefore, iron metabolism may be a key driver of sex-biased differences in cancer. In this article, we review and synthesize the existing literature examining iron's role in driving sex differences in tumor incidence, progression, response to therapy, and overall survival in different cancer types. We also explore models that could be useful in studying iron metabolism-driven sex differences in tumorigenesis.
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