In one paragraphArticle in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Jie LiThymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0006-3800-1385 Mei-Ting YangThymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2820-5940 Mami Matsuda-LennikovThymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0003-9421-3276 Felix Kalle-YoungoueThymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0004-2228-6254 Aya UshioThymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0008-3786-1687 Kenta KondoThymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9998-4676 Meleca GluckmanThymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0000-2754-1980 Kana BandoLaboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.ORCID 0000-0003-3060-8482 Takaya AbeLaboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.ORCID 0000-0001-5885-4875 Kensuke TakadaDivision of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima, Japan.ORCID 0000-0001-8999-001X Michael C KellySingle Cell Analysis Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0654-2778 Felipe Castro MartinezMucosal Immunology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3039-3445 Zuojia ChenMucosal Immunology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8151-8351 Chuan WuMucosal Immunology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2288-353X Yousuke TakahamaThymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4992-9174 Funding
Thymus biologyZIABC011806 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TAKAHAMA, YOUSUKE · 2018 to 2025
$13.5MCCR NIH HHSFrederick National Laboratory for Cancer Research 75N91019D0024Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011806NCI NIH HHSNIH HHS ZIA BC 011806
6 · The paper itselfAbstract
The chemokine receptor CCR9 regulates thymus colonization by T progenitors and intestinal accumulation of TCRγδ+ intraepithelial lymphocytes (IELs). CCR9-ligand chemokine CCL25 is expressed predominantly in the thymus and the small intestine. By engineering tissue-specific CCL25-deficient mice, we demonstrate that CCL25 locally produced by thymic and intestinal epithelial cells individually supports developing T cell localization in the thymus and TCRγδ+ IEL accumulation in the small intestine, respectively. Our results also reveal that thymic epithelial CCL25 facilitates T cell positive selection in the thymic cortex. We further find that intestinal epithelial CCL25 promotes nutrient sensing in the small intestine. These results indicate that epithelial CCL25 directs thymic T cell development and intestinal homeostasis in a tissue-specific paracrine manner.
Indexed as
Chemokines, CCHomeostasisIntestinal MucosaT-LymphocytesAnimalsEpithelial CellsIntestine, SmallMiceMice, Inbred C57BLMice, KnockoutReceptors, CCRThymus GlandCC chemokine receptor 9Ccl25 protein, mouseChemokines, CCReceptors, CCR
Identifiers
PMID42118152
PMCPMC13242286
What OpenQuestion holds
Textmetadata
LicenceTDM
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