Lipid-Substrate Interactions Lead to Bilayer Asymmetry.

Ruofei Wang, Ella Gregory, Brandon A Oswald, Tinglu Yang, Paul S Cremer

Abstract read

In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruofei WangDepartment of Chemistry, Penn State University, University Park, Pennsylvania 16802, United States.

Ella GregoryDepartment of Chemistry, Penn State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0003-3257-5725

Brandon A OswaldDepartment of Chemistry, Penn State University, University Park, Pennsylvania 16802, United States.

Tinglu YangDepartment of Chemistry, Penn State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0003-0872-8218

Paul S CremerDepartment of Chemistry, Penn State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-8524-0438

Funding

NSF CHE-2305129

6 · The paper itself

Abstract

Lipid asymmetry was probed in supported lipid bilayers (SLBs) formed by vesicle fusion on planar glass substrates and protein-coated substrates. Leaflet distribution was determined via fluorescence microscopy following bilayer unzipping. Each SLB was primarily composed of phosphatidylcholine (PC) with 0.5 mol % of a test lipid containing a tail-labeled probe. At equilibrium, the results revealed that 75% of labeled phosphatidylserine (PS) and phosphatidylethanolamine (PE) lipids partitioned into the lower leaflet adjacent to the glass surface. This preferential partitioning further increased when experiments were conducted in D

Indexed as

Lipid BilayersPhosphatidylethanolaminesHydrogen BondingPhosphatidylcholinesPhosphatidylserinesLipid BilayersPhosphatidylcholinesphosphatidylethanolaminePhosphatidylethanolaminesPhosphatidylserines

Identifiers

PMID42118149

DOI10.1021/jacs.6c04860

PMCPMC13220268

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.