Evidence map›Paper›PMID 42118147›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

The RNA-Binding Protein PARN Remodeled 3' UTR Structure Defines Poly(A)-Loading Sites to Mediate Immunoglobulin Homeostasis.

Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu and 10 more

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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Siyuan SunKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0000-3638-6724
Chen YangState Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Xiaoyu WangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Naijing HuDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Shengyao ZhangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Xinchun LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Yu ChenKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Jianan ZhaiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Xiangfeng TangNational Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing Key Laboratory of Pediatric Organ Failure, Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Wei LuNational Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing Key Laboratory of Pediatric Organ Failure, Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.
Chenxu LuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Changchang CaoState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Weiru YuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Wenhao WuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Xiaonan NieKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Fengchao WangNational Institute of Biological Sciences, Beijing, China.
Bing FangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Fazheng RenKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Yixuan LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Juan ChenKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0003-9792-7995

Funding

Beijing Life Science Academy 2024400CA0030Chinese Universities Scientific 2025TC018Henan Province Natural Science Foundation 252300421131National Natural Science Foundation 32470606National Natural Science Foundation 82502815The 111 project from the Education Ministry of China B18053
6 · The paper itself

Abstract

Class Switch Recombination (CSR) is essential for generating high-affinity antibody isotypes from IgM during adaptive humoral responses. Despite well-established roles for various transcription factors, whether CSR is subject to dedicated post-transcriptional control represents a significant gap in knowledge. By integrating conditional knockout models with SLE disease contexts, this study is the first to identify that the RNA-binding protein, poly(A)-specific ribonuclease (PARN), serves as a key positive regulator of antibody-secreting cell function. Mechanistically, PARN preferentially binds 3' UTRs and enhances the utilization of proximal poly(A) sites on a genome-wide scale in vivo. Further results show that PARN binds UGUA and AA(U/A)AAA upstream elements to form a specific spatial RNA-protein complex, through which it exerts exonuclease activity to shorten poly(A) tails, thereby decreasing mRNA stability. In addition, we identified a class of functional genes-including Foxp1-whose dynamic 3' UTR changes directly regulate antibody secretion. This study reports a novel post-transcriptional mechanism by which PARN promotes antibody production through modulation of 3' UTR length. These findings not only advance our understanding of humoral immune regulation but also highlight a potential therapeutic target for autoimmune diseases such as SLE.

Indexed as

3' Untranslated RegionsExoribonucleasesHomeostasisImmunoglobulin Class SwitchingPoly ARNA-Binding ProteinsAnimalsMice3' Untranslated RegionsExoribonucleasesPoly ARNA-Binding Proteinsalternative polyadenylation (APA)class switch recombination (CSR)poly(A)‐specific ribonuclease (PARN)RNA binding protein (RBP)systemic lupus erythematosus (SLE)

Identifiers

PMID42118147
PMCPMC13336127

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.