Evidence map›Paper›PMID 42118140›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Decoding IGLL5 Mutation-Mediated BCR Signaling: A Novel Mechanism of CD8

Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao and 3 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andi ZhaoDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Haoyu WeiDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Chenyu ZhouDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xinping SunDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Shuyan DaDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Haiyu LiuDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Zijin WangDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Hui ZhuDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Shiya ShenDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Qing ShaoDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Qi GongDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Hu LiuDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xuejuan ChenDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0001-8546-2180

Funding

Jiangsu Province's Science and Technology Project BE2020722National Natural Science Foundation of China 82171838National Natural Science Foundation of China 82273159
6 · The paper itself

Abstract

Ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) is driven by both genetic and immune microenvironmental factors, yet its pathogenic mechanisms remain incompletely understood. We previously identified IGLL5 as a recurrently mutated gene associated with poor prognosis in OAML. Functional and mechanistic analyses focusing on the S47G and A54G mutants show that these variants enhance association with the CD79A/CD79B complex, leading to persistent B-cell receptor (BCR) signaling. This signaling is accompanied by upregulation of CXCL10 and CXCL11, increased CD8

Indexed as

CD8-Positive T-LymphocytesEye NeoplasmsLymphoma, B-Cell, Marginal ZoneReceptors, Antigen, B-CellDisease ProgressionHumansMutationSignal TransductionT-Cell ExhaustionReceptors, Antigen, B-CellB‐cell receptor (BCR) signalingIGLL5 mutationsOAML (ocular adnexal MALT lymphoma)T‐cell exhaustion

Identifiers

PMID42118140
PMCPMC13335846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.