ReviewStem cells (Dayton, Ohio)2026
Regeneration of the mammalian brain: a relic of evolution?
Review in Stem cells (Dayton, Ohio), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compared to amphibians, fish, and reptiles, mammals have an impaired capacity to regenerate the brain, despite the presence of a neural stem cell pool. Here, we consider the biological significance of a stem cell source in the human brain by exploring evolutionary trade-offs that may guide retention of regenerative capacity in mammals and the risks and benefits of active neurogenesis in adults. We discuss whether reduced regenerative capacity in humans is adaptive or stochastic and examine the role of the injured and diseased brain environment in preventing efficient brain repair. We discuss the therapeutic potential of activating the latent regenerative potential of the human brain to reverse tissue damage or degeneration and whether this approach carries with it an unanticipated risk of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.