ArticleAntimicrobial agents and chemotherapy2026
Model-informed precision dosing of vancomycin in children 3 months to 18 years of age using Australia-wide data.
Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Vancomycin is used to treat serious gram-positive infections in children; however, effective dosing information for those aged 3 months to 18 years is limited. We aimed to determine an optimized dosing strategy for this age group. A population pharmacokinetic model was developed using data from The Royal Children's Hospital (RCH), Melbourne. Children aged 3 months to 18 years who received vancomycin were included. The model was externally validated with data from the Children's Hospital at Westmead (CHW), Sydney Children's Hospital (SCH), and Perth Children's Hospital (PCH). Simulations were performed to evaluate the standard dosing regimen and propose an optimized strategy, targeting an AUC
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