ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
Orchestration of PKC-Mediated Inhibition and Calcium Release-Mediated Activation of BK Currents in Rat Vascular Smooth Muscle Cells by Melatonin Confers a BK-Channel-Dependent Restraint on Melatonin-Induced Vasocontraction.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Orchestration of PKC-Mediated Inhibition and Calcium Release-Mediated Activation of BK Currents in Rat Vascular Smooth Muscle Cells by Melatonin Confers a BK-Channel-Dependent Restraint on Melatonin-Induced Vasocontraction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Circadian control of immune homeostasis in cardiovascular health and disease.Frontiers in immunology · 2026Review
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Authors and funding
4 authors.
Funding
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Abstract
Vascular smooth muscle BK channels are affected by several signaling pathways, in particular by PKC and calcium release from intracellular stores. However, little is known about how the cross-talk of these pathways is orchestrated. Melatonin is widely recognized for its role in circadian regulation, yet its vascular actions remain incompletely understood. The hypothesis that cross-talk of PLC-mediated stimulation of PKC and calcium release determines the role of the BK channel in melatonin-induced vasocontraction was tested. The patch-clamp technique was used on freshly isolated smooth muscle cells and wire myography on intact rat tail arteries. Melatonin markedly stimulates an outward current. Iberiotoxin, a specific BK channel inhibitor, abolished this effect. The effect of melatonin was not affected by 4P-PDOT, a selective MT
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