Evidence map›Paper›PMID 42117833›Full record

ArticleBiology2026

The miR-214-3p/

Huixia Wang, Ruifeng Zhong, Wenli Li, Yijia Tao, Yali Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Huixia WangHunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan Normal University, Changsha 410081, China.
Ruifeng ZhongHunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan Normal University, Changsha 410081, China.
Wenli LiHunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan Normal University, Changsha 410081, China.
Yijia TaoHunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan Normal University, Changsha 410081, China.
Yali LiHunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan Normal University, Changsha 410081, China.

Funding

Education Department of Hunan Province No. 24B0056Hunan Provincial Natural Science Foundation No. 2024JJ5257National Natural Science Foundation of China No. 31802075
6 · The paper itself

Abstract

Lysosomes are crucial for the function of fetal vacuolated enterocytes in neonatal piglets, yet how they are regulated by miRNAs remains poorly defined. Therefore, this study aimed to elucidate how miRNAs govern lysosomal homeostasis in the developing intestine. Using a neonatal piglet model of lysosomal dysfunction induced by imipramine (IMI), we identified ssc-miR-214-3p as a key down-regulated miRNA implicated in lysosomal pathways. In IPEC-J2 enterocytes, the miR-214-3p mimic ameliorated IMI cytotoxicity by restoring cell viability and migration while suppressing apoptosis. Further analysis revealed that miR-214-3p directly reversed the lysosomal defects triggered by IMI treatment. Specifically, it alleviated lysosomal alkalinization and markedly restored acid phosphatase (ACP) activity, indicating a recovery of the acidic hydrolytic environment. This restoration was also accompanied by the preservation of lysosomal membrane integrity and a consequent reduction in the nuclear translocation of transcription factor EB (TFEB). Furthermore, cathepsin D (

Indexed as

CTSDintestinal epithelial cellslysosomemiR-214-3ppiglet

Identifiers

PMID42117833
PMCPMC13162880

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.