Evidence map›Paper›PMID 42117769›Full record

ArticleJournal of virology2026

Long noncoding RNA#61 synergizes with viral PA-X to augment pyroptosis and attenuate the virulence of highly pathogenic H5N1 influenza virus in mice.

Xia Chen, Xinxin Zheng, Lei Zhang, Xinxin Cai, Xinping Hong, Siyu Hou, Xuran Ma, Zenglei Hu, Min Gu, Xiaoquan Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xia ChenKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Xinxin ZhengKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Lei ZhangKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Xinxin CaiKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Xinping HongKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Siyu HouKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Xuran MaKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Zenglei HuJoint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou, People's Republic of China.ORCID 0000-0002-8102-595X
Min GuKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Xiaoquan WangKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Ruyi GaoKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Shunlin HuKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Yu ChenKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Xiaowen LiuKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Daxin PengKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.ORCID 0000-0001-6773-5149
Xiufan LiuKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.
Jiao HuKey Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.ORCID 0000-0001-6894-4436

Funding

National Natural Science Foundation of China 32372976
6 · The paper itself

Abstract

Long non-coding RNAs (LncRNAs) play pivotal regulatory roles in various biological processes, notably in immune regulation and viral infection. We previously identified the broad anti-influenza activity for LncRNA#61. Here, we further investigate the mechanism underlying its antiviral effect, both IMPORTANCE: A current priority in anti-influenza research is developing broad-spectrum, host-directed therapeutics with low resistance risk. Here, we reveal that LncRNA#61-induced pyroptosis exerts an antiviral effect by restricting H5N1 virus replication both

Indexed as

Influenza A Virus, H5N1 SubtypeOrthomyxoviridae InfectionsPyroptosisRNA, Long NoncodingViral Nonstructural ProteinsAnimalsDogsFemaleHumansMadin Darby Canine Kidney CellsMiceMice, Inbred BALB CRepressor ProteinsVirulenceVirus ReplicationPA-X protein, influenza A virusRepressor ProteinsRNA, Long NoncodingViral Nonstructural Proteinsantiviral effecthighly pathogenic H5N1 influenza viruslong non-coding RNAPA-Xpyroptosis

Identifiers

PMID42117769
PMCPMC13289121

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.